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光动力疗法:治疗口腔病变的前沿环境。

Photodynamic therapy: the imminent milieu for treating oral lesions.

作者信息

Mohanty Neeta, Jalaluddin Md, Kotina Sreekanth, Routray Samapika, Ingale Yashwant

机构信息

HOD & Professor, Department of Oral Pathology & Microbiology, Institute of Dental Sciences , Bhubaneswar, Odisha, India .

出版信息

J Clin Diagn Res. 2013 Jun;7(6):1254-7. doi: 10.7860/JCDR/2013/5767.3088. Epub 2013 Mar 29.

DOI:10.7860/JCDR/2013/5767.3088
PMID:23905154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3708249/
Abstract

Photodynamic therapy (PDT) is used in curative and palliative treatment of head and neck squamous cell carcinoma (HNSCC) and other oral lesions. Oral infections (such as mucosal and endodontic infections, periodontal diseases, caries, and peri-implantitis) are among the specific targets where PDT can be applied Photodynamic therapy (PDT) efficacy depends on the local dose deposited in the lesion as well as oxygen availability in the lesion. Further long-term clinical studies are necessary in establishing a more specific place of the technique in the field of dentistry.

摘要

光动力疗法(PDT)用于头颈部鳞状细胞癌(HNSCC)及其他口腔病变的根治性和姑息性治疗。口腔感染(如黏膜和牙髓感染、牙周疾病、龋齿和种植体周围炎)是光动力疗法(PDT)可应用的特定靶点。光动力疗法(PDT)的疗效取决于病变部位沉积的局部剂量以及病变部位的氧可用性。在确定该技术在牙科领域更具体的应用位置方面,还需要进一步的长期临床研究。

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本文引用的文献

1
Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization.光动力疗法的机制:第一部分——光敏剂、光化学和细胞定位。
Photodiagnosis Photodyn Ther. 2004 Dec;1(4):279-93. doi: 10.1016/S1572-1000(05)00007-4.
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Successful treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical 5-aminolevulinic acid-mediated photodynamic therapy.ALA 介导的光动力疗法局部治疗 7,12-二甲基苯并蒽诱导的颊囊癌变前病变的成功治疗。
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Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus.临床评估光动力疗法治疗口腔扁平苔藓的疗效。
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Effect of erythrosine- and LED-mediated photodynamic therapy on buccal candidiasis infection of immunosuppressed mice and Candida albicans adherence to buccal epithelial cells.胭脂红和 LED 介导的光动力疗法对免疫抑制小鼠口腔念珠菌感染和白色念珠菌黏附口腔上皮细胞的影响。
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Topical photodynamic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia.局部光动力疗法对口腔疣状增生和口腔红斑白角化病非常有效。
J Oral Pathol Med. 2010 Sep;39(8):624-30. doi: 10.1111/j.1600-0714.2010.00935.x.
6
Applicator for light delivery and in situ light dosimetry during endobronchial photodynamic therapy: First measurements in humans.支气管内光动力疗法中光传输和原位光剂量测定的给药器:人体初步测量。
Lasers Med Sci. 1997 Oct;12(3):253-9. doi: 10.1007/BF02765106.
7
PHOTOFRIN-mediated photodynamic therapy for treatment of early stage (Tis-T2N0M0) SqCCa of oral cavity and oropharynx.用于治疗口腔和口咽早期(Tis-T2N0M0)鳞状细胞癌的卟吩姆钠介导的光动力疗法。
Lasers Surg Med. 2010 Jan;42(1):1-8. doi: 10.1002/lsm.20881.
8
[Photodynamic therapy: search for ideal photosensitizer].[光动力疗法:寻找理想的光敏剂]
Biomed Khim. 2009 Sep-Oct;55(5):558-69.
9
Comparison of clinical outcomes of oral erythroleukoplakia treated with photodynamic therapy using either light-emitting diode or laser light.使用发光二极管或激光进行光动力疗法治疗口腔红白斑的临床结果比较。
Lasers Surg Med. 2009 Nov;41(9):628-33. doi: 10.1002/lsm.20841.
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Eur Arch Otorhinolaryngol. 2009 Dec;266(12):1937-44. doi: 10.1007/s00405-009-0947-2. Epub 2009 Mar 17.