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通过漫射光谱法评估口腔病变局部光动力治疗反应中的病损间差异。

Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies.

作者信息

Rohrbach Daniel J, Rigual Nestor, Tracy Erin, Kowalczewski Andrew, Keymel Kenneth L, Cooper Michele T, Mo Weirong, Baumann Heinz, Henderson Barbara W, Sunar Ulas

机构信息

Department of Cell Stress Biology & PDT Center, Roswell Park Cancer Institute, Elm & Carlton St, Buffalo, NY 14263, USA.

出版信息

Biomed Opt Express. 2012 Sep 1;3(9):2142-53. doi: 10.1364/BOE.3.002142. Epub 2012 Aug 16.

DOI:10.1364/BOE.3.002142
PMID:23024908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3447556/
Abstract

Photodynamic therapy (PDT) efficacy depends on the local dose deposited in the lesion as well as oxygen availability in the lesion. We report significant interlesion differences between two patients with oral lesions treated with the same drug dose and similar light dose of 2-1[hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH)-mediated photodynamic therapy (PDT). Pre-PDT and PDT-induced changes in hemodynamic parameters and HPPH photosensitizer content, quantified by diffuse optical methods, demonstrated substantial differences between the two lesions. The differences in PDT action determined by the oxidative cross-linking of signal transducer and activator of transcription 3 (STAT3), a molecular measure of accumulated local PDT photoreaction, also showed >100-fold difference between the lesions, greatly exceeding what would be expected from the slight difference in light dose. Our results suggest diffuse optical spectroscopies can provide in vivo metrics that are indicative of local PDT dose in oral lesions.

摘要

光动力疗法（PDT）的疗效取决于病变部位沉积的局部剂量以及病变部位的氧可用性。我们报告了两名接受相同药物剂量和相似光剂量（2-1[己氧基乙基]-2-去乙烯基焦脱镁叶绿酸-a（HPPH）介导的光动力疗法（PDT））治疗的口腔病变患者之间病变部位存在显著差异。通过漫射光学方法量化的 PDT 前和 PDT 诱导的血流动力学参数及 HPPH 光敏剂含量变化表明，这两个病变之间存在实质性差异。由转录信号转导子和激活子 3（STAT3）的氧化交联所确定的 PDT 作用差异，这是累积局部 PDT 光反应的一种分子测量方法，两个病变之间也显示出超过 100 倍的差异，大大超过了光剂量微小差异所预期的范围。我们的结果表明，漫射光学光谱学可以提供指示口腔病变局部 PDT 剂量的体内指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/a0544f01c11e/boe-3-9-2142-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/e11442d6bdee/boe-3-9-2142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/4b71f0951abd/boe-3-9-2142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/7b0d7ced8853/boe-3-9-2142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/960af402a245/boe-3-9-2142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/dc4c25de3f3e/boe-3-9-2142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/0e4bbda2a6b9/boe-3-9-2142-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/a0544f01c11e/boe-3-9-2142-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/e11442d6bdee/boe-3-9-2142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/4b71f0951abd/boe-3-9-2142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/7b0d7ced8853/boe-3-9-2142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/960af402a245/boe-3-9-2142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/dc4c25de3f3e/boe-3-9-2142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/0e4bbda2a6b9/boe-3-9-2142-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe0/3447556/a0544f01c11e/boe-3-9-2142-g007.jpg

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