Watson A P, Rosen E S
District General Hospital, Southport, Merseyside.
Br J Ophthalmol. 1990 Aug;74(8):458-61. doi: 10.1136/bjo.74.8.458.
Injection of fluorescein intravenously for fundal angiography is associated with a high incidence of minor adverse effects (21%) but a very low incidence of serious (life threatening) reactions (0.05%). A serious reaction may occur without warning in a patient with no history of atopy. There are no reports of oral fluorescein causing a serious reaction, and minor adverse effects are uncommon. A study was undertaken to determine optimum conditions for oral fluorescein angiography. Capsules proved more convenient than a solution for ingestion of fluorescein. A dose of 25 mg/kg body weight produced good quality angiograms in 75% of the patients. The best pictures were obtained by photographing the fundus after 40 and 60 minutes.
静脉注射荧光素进行眼底血管造影时，轻微不良反应的发生率较高（21%），但严重（危及生命）反应的发生率极低（0.05%）。在无特应性病史的患者中，严重反应可能毫无征兆地发生。尚无口服荧光素引起严重反应的报道，轻微不良反应也不常见。开展了一项研究以确定口服荧光素血管造影的最佳条件。结果表明，胶囊比溶液更便于摄入荧光素。25mg/kg体重的剂量在75%的患者中产生了质量良好的血管造影片。在40分钟和60分钟后拍摄眼底可获得最佳图像。
