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[新型人类腺病毒的最新进展]

[Recent advance in new types of human adenovirus].

作者信息

Huang Guo-Hong, Xu Wen-Bo

机构信息

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

出版信息

Bing Du Xue Bao. 2013 May;29(3):342-8.

Abstract

Adenoviruses are double stranded DNA viruses that cause an array of diseases. More than 60 types of human adenovirus have been reported so far. The discovery and division of human adenovirus types 52-67 are based on the genomic sequencing and bioinformatic analysisy and different from the pre-existing 51 serotypes identified by traditional serological methods in composition and pathogenicity. The majority of new types of human adenovirus are homologous recombination within the same subgenus, and as a result, certain new serotypes acquire different pathogenicity. Recombination is a common evolutionary way for human adenovirus, however, the mechanism of recombination and potenital danger to human remain unknown. As new types of human adenovirus have been receiving increasing attention, in this review, the latest progress in new types of human adenovirus is summarized.

摘要

腺病毒是双链DNA病毒,可引发一系列疾病。迄今为止,已报道了60多种人类腺病毒。人类腺病毒52 - 67型的发现和划分基于基因组测序和生物信息学分析,在组成和致病性方面与传统血清学方法鉴定的已有的51种血清型不同。大多数新型人类腺病毒是在同一亚属内发生同源重组,因此,某些新血清型具有不同的致病性。重组是人类腺病毒常见的进化方式,然而,重组机制及其对人类的潜在危险仍然未知。随着新型人类腺病毒越来越受到关注,在本综述中,总结了新型人类腺病毒的最新研究进展。

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