8 Foxlair Court, Durham, North Carolina 27712, United States.
Chem Res Toxicol. 2013 Sep 16;26(9):1312-9. doi: 10.1021/tx4001623. Epub 2013 Aug 19.
A significant number of low molecular weight metal complexes as well as metal-free compounds that are capable of scavenging superoxide and/or other radicals and reactive species in simple systems have been proposed to be used as potential drugs in the case of various diseases and/or as antiaging agents. Some have been used or suggested to be used as diagnostic tools for the involvement of such species in biological processes. In the present work, analysis of such claims indicates that their use as specific detectors of superoxide or of other reactive oxygen species is unsupported and might be confusing. Many of these compounds exert beneficial effects by counteracting the toxic effects of oxidative stress in a significant number of models of pathological processes. However, it is concluded that these actions are more likely due to other effects including prooxidant actions and that their beneficial effects also may be exerted in pathological processes that do not practically involve reactive oxygen species. Adaptation may be a common mode of action explaining a sizable portion of the beneficial effect of the so-called mimics and other compounds including prooxidants.
已经提出了相当数量的能够在简单体系中清除超氧阴离子和/或其他自由基和活性物质的低分子量金属配合物以及无金属化合物，作为各种疾病的潜在药物和/或抗衰老剂。其中一些已被用于或建议用于作为此类物质参与生物过程的诊断工具。在目前的工作中，对这些说法的分析表明，将它们用作超氧阴离子或其他活性氧物种的特定探测器是没有根据的，可能会产生混淆。许多这些化合物通过对抗氧化应激在大量病理过程模型中的毒性作用发挥有益的作用。然而，结论是，这些作用更可能是由于其他作用包括促氧化剂作用，并且它们的有益作用也可能在实际上不涉及活性氧的病理过程中发挥作用。适应可能是解释所谓模拟物和其他包括促氧化剂在内的化合物的大部分有益作用的常见作用模式。
