Woźniak Michał, Czyz Małgorzata
Zakład Biologii Molekularnej Nowotworów, Uniwersytet Medyczny, Łódź.
Postepy Hig Med Dosw (Online). 2008 Nov 5;62:613-24.
Superoxide, and its derivatives hydrogen peroxide, hydrogen peroxide, and peroxynitrite, play an important role in aging and in several diseases, including cancer, diabetes, inflammation, neurodegenerative and vascular disorders. Increased level of reactive oxygen species leading to severe organ damage could also be a consequence of applied therapy, such as radiation therapy, chemotherapy,reperfusion after ischemia, or transplantation. A new approach to protect normal tissues without jeopardizing the efficacy of treatment may be to apply specific catalytic antioxidants as adjuncts to the therapy. In this review a number of synthetic low-molecular-weight agents are discussed that may be used as mimetics of superoxide dismutase enzymes (SODm) to treat diseases of various etiologies and to protect healthy tissues during therapy.
超氧化物及其衍生物过氧化氢、过氧化氢和过氧亚硝酸盐在衰老以及包括癌症、糖尿病、炎症、神经退行性疾病和血管疾病在内的多种疾病中起重要作用。活性氧水平升高导致严重的器官损伤也可能是应用治疗（如放射治疗、化疗、缺血后再灌注或移植）的结果。一种在不损害治疗效果的情况下保护正常组织的新方法可能是应用特定的催化抗氧化剂作为治疗的辅助手段。在这篇综述中，讨论了一些合成的低分子量药物，它们可用作超氧化物歧化酶模拟物（SODm）来治疗各种病因的疾病，并在治疗期间保护健康组织。
