用于各种材料的多功能表面改性以获得极端润湿性的光反应性磷脂聚合物的合成。

Synthesis of photoreactive phospholipid polymers for use in versatile surface modification of various materials to obtain extreme wettability.

机构信息

Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

出版信息

ACS Appl Mater Interfaces. 2013 Aug 14;5(15):6832-6. doi: 10.1021/am402051e. Epub 2013 Aug 5.

DOI:10.1021/am402051e

PMID:23905848

Abstract

We synthesized photoreactive phospholipid polymers for use in the versatile surface modification of various materials. The photoreactive methacrylate derivative 2-methacryloyloxyethyl-4-azidobenzoate (MPAz) was synthesized. MPAz was copolymerized with 2-methacryloyloxyethyl phosphorylcholine (MPC) to obtain poly(MPC-co-MPAz) (PMPAz) and with both MPC and n-butyl methacrylate (BMA) to obtain poly(MPC-co-BMA-co-MPAz) (PMBPAz). PMPAz and PMBPAz were bound to the surfaces of various materials, including polymers, glass, and metals, by exposure to ultraviolet irradiation. The azide groups in the MPAz units played a role in the surface anchoring; the polymer was bound covalently to the substrate. After the photoreaction, the surfaces were converted from hydrophobic to superhydrophilic, and their cell adhesion was effectively suppressed.

摘要

我们合成了光反应性磷脂聚合物，用于各种材料的多功能表面修饰。合成了光反应性甲基丙烯酸酯衍生物 2-甲基丙烯酰氧基乙基-4-叠氮苯甲酸酯（MPAz）。MPAz 与 2-甲基丙烯酰氧基乙基磷酸胆碱（MPC）共聚得到聚（MPC-co-MPAz）（PMPAz），与 MPC 和正丁基甲基丙烯酸酯（BMA）共聚得到聚（MPC-co-BMA-co-MPAz）（PMBPAz）。通过暴露于紫外光照射，PMPAz 和 PMBPAz 结合到各种材料的表面上，包括聚合物、玻璃和金属。MPAz 单元中的叠氮基团在表面锚定中起作用；聚合物通过共价键结合到基底上。光反应后，表面从疏水性转变为超亲水性，其细胞黏附被有效抑制。