Denniff Philip, Woodford Lynsey, Spooner Neil
Drug Metabolism & Pharmacokinetics, Platform Technology & Science, GlaxoSmithKline Research & Development, Ware, Hertfordshire SG12 0DP, UK.
Bioanalysis. 2013 Aug;5(15):1863-71. doi: 10.4155/bio.13.137.
For shipping and storage, dried blood spot (DBS) samples must be sufficiently dry to protect the integrity of the sample. When the blood is spotted the humidity has the potential to affect the size of the spot created and the speed at which it dries.
The area of DBS produced on three types of substrates were not affected by the humidity under which they were generated. DBS samples reached a steady moisture content 150 min after spotting and 90 min for humidities less than 60% relative humidity. All packaging materials examined provided some degree of protection from external extreme conditions. However, none of the packaging examined provided a total moisture barrier to extreme environmental conditions.
Humidity was shown not to affect the spot area and DBS samples were ready for shipping and storage 2 h after spotting. The packing solutions examined all provided good protection from external high humidity conditions.
为了运输和储存，干血斑（DBS）样本必须充分干燥以保护样本的完整性。当血液点样时，湿度有可能影响所形成斑点的大小及其干燥速度。
在三种类型的基质上产生的DBS面积不受产生时湿度的影响。DBS样本在点样后150分钟达到稳定的水分含量，对于相对湿度低于60%的情况则为90分钟。所有检测的包装材料都提供了一定程度的抵御外部极端条件的保护。然而，所检测的包装中没有一种能对极端环境条件提供完全的防潮屏障。
结果表明湿度不影响斑点面积，DBS样本在点样后2小时即可用于运输和储存。所检测的包装解决方案都能很好地抵御外部高湿度条件。
