Haahtela T, Lindholm H, Björkstén F, Koskenvuo K, Laitinen L A
Department of Allergic Diseases, University Central Hospital, Helsinki, Finland.
BMJ. 1990 Aug 4;301(6746):266-8. doi: 10.1136/bmj.301.6746.266.
To determine the prevalence of asthma in cohorts of Finnish young men in the period 1926-89.
A retrospective analysis using reports and statistics of Finnish defence forces.
Call up examinations of candidates for military conscription and examination of conscripts discharged because of poor health.
Roughly 900,000 men--that is, 98% of men of conscription age--examined in 1966-89 and a proportional but unknown number examined in 1926-61.
Asthma recognised at call up examination, exemption from military service, and discharge from military service because of asthma.
During 1926-61 the prevalence of asthma recorded at call up examinations remained steady at between 0.02% and 0.08%. Between 1961 and 1966, however, a continuous, linear rise began, the prevalence increasing from 0.29% in 1966 to 1.79% in 1989--that is, representing a sixfold increase. Compared with 1961 the rise was 20-fold. From 1966 to 1989 the sum of exemptions and discharges from military service due to asthma increased analogously sixfold.
If the apparent increase in asthma detected in Finnish young men was due entirely to improved diagnostic methods and other confounding effects then some 95% of cases must have gone undiagnosed in the years before 1966. This seems inconceivable, which suggests that much of the increase was real. This conclusion is strengthened by the observed rise in exemptions and discharges due to asthma.
确定1926年至1989年间芬兰年轻男性群体中哮喘的患病率。
利用芬兰国防军的报告和统计数据进行回顾性分析。
征兵候选人的征召体检以及因健康状况不佳而退伍的新兵体检。
1966年至1989年间接受检查的约90万名男性,即应征年龄男性的98%,以及1926年至1961年间接受检查的比例未知但数量成比例的男性。
征召体检时确诊的哮喘、免服兵役以及因哮喘退伍。
在1926年至1961年间,征召体检记录的哮喘患病率稳定在0.02%至0.08%之间。然而,在1961年至1966年间,患病率开始持续线性上升,从1966年的0.29%增至1989年的1.79%,即增长了六倍。与1961年相比,增长了20倍。从1966年到1989年,因哮喘免服兵役和退伍的总数相应增加了六倍。
如果在芬兰年轻男性中检测到的哮喘患病率明显上升完全归因于诊断方法的改进和其他混杂因素,那么在1966年之前的几年里,约95%的病例肯定未被诊断出来。这似乎令人难以置信,这表明大部分增长是真实的。哮喘导致的免服兵役和退伍人数的上升进一步支持了这一结论。