Frontela-Saseta Carmen, González-Bermúdez Carlos A, García-Marcos Luis
Department of Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", 30100 Murcia, Spain.
Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, 30003 Murcia, Spain.
J Clin Med. 2020 Jul 1;9(7):2063. doi: 10.3390/jcm9072063.
The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich in sugars that can lead to changes in immune cells and their responsiveness, by different mechanisms that have yet to be totally clarified. Inflammatory processes are perpetuated through different pathways, in which adipose tissue is a major factor. High fat stores in overweight and obesity accumulate energy but the endocrine function is also producing and releasing different bioactive compounds, adipokines, known to be pro-inflammatory and which play an important role in the pathogenesis of asthma. This review therefore explores the latest evidence regarding the adverse effect of the Western diet on adipose tissue inflammation and its causative effect on the asthma epidemic.
西方生活方式是一个复杂的概念，其饮食作为不同因素的主要核心，对健康产生有害影响，降低预期寿命并导致生活质量低下。这类饮食的特点是热量高，主要由饱和脂肪提供，且富含糖分，这些糖分可通过尚未完全阐明的不同机制导致免疫细胞及其反应性发生变化。炎症过程通过不同途径持续存在，其中脂肪组织是一个主要因素。超重和肥胖人群中大量的脂肪储存积累了能量，但内分泌功能也在产生和释放不同的生物活性化合物，即脂肪因子，已知这些脂肪因子具有促炎作用，并且在哮喘的发病机制中起重要作用。因此，本综述探讨了有关西方饮食对脂肪组织炎症的不利影响及其对哮喘流行的致病作用的最新证据。
