Division of Hepatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2013 Aug;29(8):430-5. doi: 10.1016/j.kjms.2012.12.004. Epub 2013 Feb 20.
Gallbladder (GB) stones have been associated with several metabolic factors and liver diseases. This community-based study aimed at investigating the prevalence rate of GB stones and its associated factors in a hepatitis B virus (HBV)/hepatitis C virus (HCV)-endemic township in southern Taiwan. A total of 1701 residents (689 males and 1012 females; mean age: 51.2 ± 16.0 years) were enrolled in this prospectively designed screening project. Serum biochemistry tests, including testing for levels of serum aspartate aminotransferase, alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), and antibody to HCV (anti-HCV) were conducted. In addition, a hepatobiliary ultrasonographic (US) examination was also conducted. Of the 1701 residents, 243 (14.3%) and 475 (27.9%) were found to be positive for HBsAg and anti-HCV, respectively. Results of the US examination revealed the prevalence rate of GB stone and fatty liver to be 6.8% and 55.6%, respectively. Using univariate analyses we found that significantly higher proportions of the participants with GB stone were male, over 50 years of age, positive for anti-HCV (p = 0.001, p < 0.001, and p = 0.001, respectively), with significantly higher mean age and ALT level (p ≤ 0.001 and p = 0.048, respectively) than did those without GB stone. By applying multivariate analyses, male gender, positive anti-HCV, and older age (>50 year) were identified as independent factors associated with the formation of GB stones. Anti-HCV was associated with GB stones in males but not in females in both univariate and multivariate analyses. GB stones were found to have a prevalence rate of 6.8% in this HCV/HBV hyperendemic township and are associated with higher mean age. A correlation between chronic hepatitis C and GB stones is observed only among males.
胆囊（GB）结石与多种代谢因素和肝脏疾病有关。本项基于社区的研究旨在调查乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）流行地区台湾南部一个乡镇的胆囊结石患病率及其相关因素。共有 1701 名居民（689 名男性和 1012 名女性；平均年龄：51.2±16.0 岁）参与了这项前瞻性设计的筛查项目。进行了血清生化测试，包括检测血清天门冬氨酸氨基转移酶、丙氨酸氨基转移酶（ALT）、乙型肝炎表面抗原（HBsAg）和抗丙型肝炎病毒抗体（抗-HCV）水平。此外，还进行了肝胆超声（US）检查。在 1701 名居民中，243 名（14.3%）和 475 名（27.9%）HBsAg 和抗-HCV 检测结果为阳性。US 检查结果显示胆囊结石和脂肪肝的患病率分别为 6.8%和 55.6%。通过单因素分析，我们发现胆囊结石患者中男性、年龄超过 50 岁、抗-HCV 阳性的比例显著较高（p=0.001，p<0.001，p=0.001），年龄和 ALT 水平也显著较高（p≤0.001，p=0.048）。通过多因素分析，男性、抗-HCV 阳性和年龄较大（>50 岁）被确定为与胆囊结石形成相关的独立因素。在单因素和多因素分析中，抗-HCV 与男性的胆囊结石相关，但与女性无关。在这个 HCV/HBV 高发地区，胆囊结石的患病率为 6.8%，与较高的平均年龄有关。慢性丙型肝炎与胆囊结石之间的相关性仅在男性中观察到。
