Xu Ru-Yi, Ye Ping, Sheng Li, Luo Lei-Ming, Wu Hong-Mei, Xiao Wen-Kai
Second Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Apr;41(4):288-92.
To analyze the association between single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor(PPAR) and arterial stiffness in adult Chinese population (> 50 years).
Cardiovascular risk factors from participants of Beijing epidemiological investigation were analyzed. Carotid-femoral pulse wave velocity (cfPWV) was measured by Complior system. The subjects were divided into normal arterial stiffness group (cfPWV < 12 m/s, n = 844) and increased arterial stiffness group (cfPWV > 12 m/s, n = 530). Three valid SNPs including rs1053049, rs1800234 and rs8192678 in the PPAR and PPARγC1a gene were genotyped by TaqMan allelic discrimination assays.
The age [(67.9 ± 8.8) years vs. (58.0 ± 9.7) years], prevalence of hypertension [71.1% (377/530) vs. 30.5% (257/844)] and diabetes mellitus [21.7% (115/530) vs. 11.0% (93/844)] were all significantly higher in increased arterial stiffness group than in normal group (all P < 0.05). The frequencies of CC, CT and TT type of rs8192678 [CC: 32.2% (272/844) vs. 30.8% (163/530), CT: 48.7% (411/844) vs. 52.1% (276/530), TT: 19.1% (161/844) vs. 17.2% (91/530)], rs1053049 [CC: 55.7% (470/844) vs. 51.3% (272/530), CT: 36.7% (310/844) vs. 39.1% (207/530), TT: 7.6% (64/844) vs. 9.6% (51/530)] and rs1800234 [CC: 88.4% (746/844) vs. 90.4% (479/530), CT + TT: 11.6% (98/844) vs. 9.6% (51/530)] were similar between the two groups. There was also no association between haplotypes and the increased arterial stiffness in this cohort.
In this community-based population, we found that aging, hypertension and diabetes mellitus were associated but SNPs of PPAR and PPARγC1a were not associated with arterial stiffness.
分析过氧化物酶体增殖物激活受体（PPAR）单核苷酸多态性（SNP）与中国成年人群（>50岁）动脉僵硬度之间的关联。
分析北京流行病学调查参与者的心血管危险因素。采用Complior系统测量颈股脉搏波速度（cfPWV）。将研究对象分为动脉僵硬度正常组（cfPWV<12m/s，n=844）和动脉僵硬度增加组（cfPWV>12m/s，n=530）。通过TaqMan等位基因鉴别分析对PPAR和PPARγC1a基因中的3个有效SNP（rs1053049、rs1800234和rs8192678）进行基因分型。
动脉僵硬度增加组的年龄[（67.9±8.8）岁 vs.（58.0±9.7）岁]、高血压患病率[71.1%（377/530） vs. 30.5%（257/844）]和糖尿病患病率[21.7%（115/530） vs. 11.0%（93/844）]均显著高于正常组（均P<0.05）。rs8192678的CC、CT和TT基因型频率[CC：32.2%（272/844） vs. 30.8%（163/530），CT：48.7%（411/844） vs. 52.1%（276/530），TT：19.1%（161/844） vs. 17.2%（91/530）]、rs1053049的基因型频率[CC：55.7%（470/844） vs. 51.3%（272/530），CT：36.7%（310/844） vs. 39.1%（207/530），TT：7.6%（64/844） vs. 9.6%（51/530）]以及rs1800234的基因型频率[CC：88.4%（746/844） vs. 90.4%（479/530），CT+TT：11.6%（98/844） vs. 9.6%（51/530）]在两组之间相似。该队列中，单倍型与动脉僵硬度增加之间也无关联。
在这个基于社区的人群中，我们发现衰老、高血压和糖尿病之间存在关联，但PPAR和PPARγC1a的SNP与动脉僵硬度无关。
