Liang Jun, Qiu Qinqin, Gong Ying, Liu Xuekui, Dou Lianjun, Zou Caiyan, Wang Yu, Qi Lu
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, The Affiliated XuZhou Hospital of Medical College of Southeast University, Jiangsu, China; Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, Jiangsu, China.
J Clin Hypertens (Greenwich). 2015 May;17(5):395-400. doi: 10.1111/jch.12516. Epub 2015 Feb 26.
The authors examined whether the adiponectin gene (ADIPOQ) variant was associated with blood pressure and arterial stiffness in Chinese adults. A genome-wide association study of the adiponectin variant rs864265 in the ADIPOQ gene was genotyped in a total of 2364 participants. After adjustment for sex, age, body mass index (BMI), fasting glucose, and lipids, participants carrying the T allele of rs864265 showed a greater increase in carotid-femoral pulse wave velocity (cfPWV) and systolic blood pressure (SBP). Further adjustment for blood pressure did not appreciably change the association with cfPWV. The authors found significant interactions between rs864265 and BMI, waist circumference, body fat percentage, and SBP in relation to cfPWV (P for interaction = .035, .001, .003, .013, respectively). The T allele of rs864265 was associated with high blood pressure and arterial stiffness. BMI, body fat percentage, waist circumference, and SBP might modify the effects of genetic polymorphism on arterial stiffness.
作者研究了脂联素基因（ADIPOQ）变异与中国成年人血压及动脉僵硬度之间是否存在关联。对总共2364名参与者进行了ADIPOQ基因中脂联素变异rs864265的全基因组关联研究基因分型。在对性别、年龄、体重指数（BMI）、空腹血糖和血脂进行校正后，携带rs864265的T等位基因的参与者在颈股脉搏波速度（cfPWV）和收缩压（SBP）方面有更大幅度的升高。对血压进行进一步校正并没有明显改变与cfPWV的关联。作者发现，rs864265与BMI、腰围、体脂百分比和SBP之间在cfPWV方面存在显著的相互作用（交互作用P值分别为0.035、0.001、0.003、0.013）。rs864265的T等位基因与高血压和动脉僵硬度相关。BMI、体脂百分比、腰围和SBP可能会改变基因多态性对动脉僵硬度的影响。
