Imperial College, Surgery and Cancer, ICTEM, Du Cane Road, Hammersmith, London, UK.
Org Biomol Chem. 2013 Sep 21;11(35):5772-81. doi: 10.1039/c3ob40897c.
The aim of this perspective is to critically review the three most prominent bioorthogonal reactions that are used presently, on both a purely chemical level and in the context of biological systems. This includes the uses both for synthesis of therapeutic molecules, modification of large biomolecules or antibodies, and in particular, the exciting use in the field of 'pre-targeting', for both possible treatment and imaging technologies. We will compare the validity of each reaction when compared to others, and their usefulness in biological systems, as each methodology has clear advantages over the others in differing environments.
本文旨在从纯粹的化学角度和生物系统的角度，批判性地回顾目前应用最广泛的三种生物正交反应。这包括治疗分子的合成、大分子或抗体的修饰，特别是在“预靶向”领域的应用，可用于治疗和成像技术。我们将比较每种反应与其他反应的有效性及其在生物系统中的有用性，因为每种方法在不同的环境下都有明显的优势。
