在染色体脆弱位点有一个活跃的解旋酶。
A blooming resolvase at chromosomal fragile sites.
出版信息
Nat Cell Biol. 2013 Aug;15(8):883-5. doi: 10.1038/ncb2812.
DOI:10.1038/ncb2812
PMID:23907189
Abstract
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
摘要
常见脆弱位点（CFSs）是染色体区域，在有丝分裂过程中，特别是在复制应激后，容易形成断裂或缺口。调节 CFS 表达并促进安全染色单体传递到子细胞的机制尚不清楚。现在表明，CFS 的表达反映了 MUS81-EME1 解旋酶复合物的活性，该复合物与 BLM 解旋酶的溶解作用合作，以防止不受控制的染色体断裂并促进基因组完整性。
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