将 HSCs 与其起源相联系。
Linking HSCs to their youth.
出版信息
Nat Cell Biol. 2013 Aug;15(8):885-7. doi: 10.1038/ncb2817.
DOI:10.1038/ncb2817
PMID:23907190
Abstract
Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.
摘要
胎儿造血干细胞（HSCs）自我更新能力很强，可以从头开始构建血液系统。蛋白质 Lin28b 负调控 microRNA let-7，从而保持其靶标 Hmga2 的高水平，从而赋予胎儿 HSCs 高自我更新能力。该调节回路可通过实验进行调节，以增强静止的成人 HSCs 的低自我更新活性。
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