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将 HSCs 与其起源相联系。

Linking HSCs to their youth.

出版信息

Nat Cell Biol. 2013 Aug;15(8):885-7. doi: 10.1038/ncb2817.

DOI:10.1038/ncb2817
PMID:23907190
Abstract

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

摘要

胎儿造血干细胞（HSCs）自我更新能力很强，可以从头开始构建血液系统。蛋白质 Lin28b 负调控 microRNA let-7，从而保持其靶标 Hmga2 的高水平，从而赋予胎儿 HSCs 高自我更新能力。该调节回路可通过实验进行调节，以增强静止的成人 HSCs 的低自我更新活性。

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Nat Cell Biol. 2013 Aug;15(8):916-25. doi: 10.1038/ncb2783. Epub 2013 Jun 30.
2
Stem cell metabolism in tissue development and aging.组织发育和衰老中的干细胞代谢。
Development. 2013 Jun;140(12):2535-47. doi: 10.1242/dev.091777.
3
Lin28: primal regulator of growth and metabolism in stem cells.Lin28：干细胞中生长和代谢的原始调节因子。
种系双等位基因改变易患新生儿青少年骨髓单核细胞白血病样疾病。
Haematologica. 2024 Aug 1;109(8):2542-2554. doi: 10.3324/haematol.2023.283917.
4
Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation.层状免疫和层状白血病形成：小儿白血病起始的发育受限机制。
Immunol Rev. 2023 May;315(1):197-215. doi: 10.1111/imr.13180. Epub 2023 Jan 2.
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Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis.定量分析氧化还原蛋白质组揭示了在发育性造血的基本过程中起作用的氧化敏感蛋白巯基。
Redox Biol. 2022 Jul;53:102343. doi: 10.1016/j.redox.2022.102343. Epub 2022 May 23.
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Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice.年龄依赖性的 Igf2bp2 对造血干细胞基因调控、功能和衰老的影响。
Blood. 2022 Apr 28;139(17):2653-2665. doi: 10.1182/blood.2021012197.
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