组织发育和衰老中的干细胞代谢。
Stem cell metabolism in tissue development and aging.
机构信息
Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
Development. 2013 Jun;140(12):2535-47. doi: 10.1242/dev.091777.
Abstract
Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to be a mere consequence of the state of a cell, metabolism is now known to play a pivotal role in dictating whether a cell proliferates, differentiates or remains quiescent. Here, we review recent studies of metabolism in stem cells that have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of adult stem cells, and during the reprogramming of somatic cells to pluripotency. These insights promise to inform strategies for the directed differentiation of stem cells and to offer the potential for novel metabolic or pharmacological therapies to enhance regeneration and the treatment of degenerative disease.
摘要
近年来，代谢组学和计算分析的进展加深了我们对特定代谢途径在决定细胞命运中的作用的认识。代谢曾经被认为只是细胞状态的结果，而现在已知它在决定细胞是增殖、分化还是静止中起着关键作用。在这里，我们回顾了最近关于干细胞代谢的研究，这些研究揭示了在成体干细胞成熟过程中和体细胞重编程为多能性过程中，糖酵解、线粒体氧化磷酸化和氧化应激之间的平衡发生了变化。这些见解有望为指导干细胞的定向分化提供策略，并为增强再生和治疗退行性疾病提供新的代谢或药理学治疗的潜力。
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本文引用的文献
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Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma.己糖激酶-2 介导的有氧糖酵解是小脑神经发生和髓母细胞瘤发病机制的重要组成部分。
Cancer Metab. 2013 Jan 23;1(1):2. doi: 10.1186/2049-3002-1-2.
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Lin28: primal regulator of growth and metabolism in stem cells.Lin28：干细胞中生长和代谢的原始调节因子。
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Influence of metabolism on epigenetics and disease.代谢对表观遗传学和疾病的影响。
Cell. 2013 Mar 28;153(1):56-69. doi: 10.1016/j.cell.2013.03.004.
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Small molecule-based approaches to adult stem cell therapies.基于小分子的成体干细胞治疗方法。
Annu Rev Pharmacol Toxicol. 2013;53:107-25. doi: 10.1146/annurev-pharmtox-011112-140300.
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Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.线粒体磷酸酶 PTPMT1 的代谢调节对于造血干细胞分化是必需的。
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Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.PDK 对糖酵解的调节可作为造血干细胞细胞周期静止的代谢检查点。
Cell Stem Cell. 2013 Jan 3;12(1):49-61. doi: 10.1016/j.stem.2012.10.011.
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Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency.体细胞重编程为多能性过程中高度协调的蛋白质组动力学。
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