Wang R L, Tan Y B
Department of Pathology, Tianjin Medical College.
Zhonghua Bing Li Xue Za Zhi. 1990 Jun;19(2):90-3.
97 cases of thyroid carcinoma originated from follicular epithelium were investigated by using histological and immunohistochemical techniques with special reference to lectin distribution. According to the WHO histological typing of thyroid tumours, these cases were divided into three categories as follows: papillary carcinoma of thyroid (PCT) 56, follicular carcinoma of thyroid (FCT) 31 and undifferentiated carcinoma of thyroid (UCT) 10. Results showed that three different kinds of thyroid carcinoma presented various hormone function and distribution of lectins. The positive rate of Tg immunoreactivity was significantly different between these three kinds of tumour, i.e. PCT greater than FCT greater than UCT. Additionally, the positive rate of T4 and T3 immunoreactivity was lower than that of Tg. Some Gastrin, SS and calcitonin positive cells were also recognized in carcinoma of thyroid. Lectin--binding rate of WGA, PNA, SBA and UEA to 97 cases of thyroid carcinoma and 9 cases of normal thyroid tissue revealed that different lectin had a selective binding activity to various types of thyroid carcinoma and normal thyroid cells. From the data obtained, it seemed that the morphological differentiation of thyroid carcinoma was in correspondence with difference of function, and the extent of cell differentiation may be closely related to the biological behavior of the tumour.
采用组织学和免疫组织化学技术，特别参照凝集素分布情况，对97例起源于滤泡上皮的甲状腺癌进行了研究。根据世界卫生组织甲状腺肿瘤的组织学分类，这些病例分为以下三类：甲状腺乳头状癌（PCT）56例、甲状腺滤泡癌（FCT）31例和甲状腺未分化癌（UCT）10例。结果显示，三种不同类型的甲状腺癌呈现出不同的激素功能和凝集素分布。这三种肿瘤之间Tg免疫反应阳性率有显著差异，即PCT大于FCT大于UCT。此外，T4和T3免疫反应阳性率低于Tg。在甲状腺癌中还识别出一些胃泌素、生长抑素和降钙素阳性细胞。WGA、PNA、SBA和UEA对97例甲状腺癌和9例正常甲状腺组织的凝集素结合率显示，不同的凝集素对各种类型的甲状腺癌和正常甲状腺细胞具有选择性结合活性。从获得的数据来看，甲状腺癌的形态学分化与功能差异相对应，细胞分化程度可能与肿瘤的生物学行为密切相关。
