Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk Bristol, UK.
Front Synaptic Neurosci. 2013 Jul 30;5:2. doi: 10.3389/fnsyn.2013.00002. eCollection 2013.
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviors. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organization of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity, and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus.
胆碱能隔海马投射从内侧隔区到海马被认为通过调节海马网络的特性在认知中具有重要作用。然而，海马内乙酰胆碱释放的确切空间和时间模式仍不清楚，使得难以定义胆碱能传递在海马依赖行为中的特定作用。这在一定程度上是由于缺乏能够特异性干预和记录胆碱能传递的工具。在这里，我们回顾了隔海马胆碱能投射和海马乙酰胆碱受体的组织，以及胆碱能传递在调节细胞兴奋性、突触可塑性和节律性网络振荡中的作用。我们指出了一些仍未解决的悬而未决的问题，并讨论了最近开发的技术的潜力，以对海马的胆碱能传入的功能进行彻底的重新评估。
