Tsotsokou Giota, Fassea Milena, Papatheodoropoulos Costas
Laboratory of Physiology, Department of Medicine, University of Patras, Pátrai, West Greece, Greece.
MicroPubl Biol. 2024 Dec 19;2024. doi: 10.17912/micropub.biology.001367. eCollection 2024.
Cholinergic transmission fundamentally modulates information processing in the brain via muscarinic receptors. Using electrophysiological recordings of population spikes from the CA1 region, we found that the muscarinic receptor agonist carbachol (CCh, 1 μM) enhances the basal excitation level in the dorsal but not ventral hippocampus. Using a frequency stimulation protocol, we found that CCh transforms depression of neuronal output into facilitation (at 3-30 Hz) in the ventral hippocampus while only lessening depression in the dorsal hippocampus, suggesting that muscarinic transmission boosts basal neuronal activation in the dorsal hippocampus and strongly facilitates the output of the ventral hippocampus in a frequency-dependent manner.
胆碱能传递通过毒蕈碱受体从根本上调节大脑中的信息处理。通过对CA1区群体峰电位进行电生理记录，我们发现毒蕈碱受体激动剂卡巴胆碱（CCh，1 μM）可增强背侧海马而非腹侧海马的基础兴奋水平。采用频率刺激方案，我们发现CCh可将腹侧海马中神经元输出的抑制转化为易化（在3 - 30 Hz时），而在背侧海马中仅减轻抑制，这表明毒蕈碱传递增强了背侧海马中基础神经元的激活，并以频率依赖的方式强烈促进腹侧海马的输出。
