Eusebio E B, Graham J, Mody N
Department of Surgery, Southern Illinois University School of Medicine, Springfield.
Dis Colon Rectum. 1990 Sep;33(9):770-2. doi: 10.1007/BF02052324.
The majority of patients with idiopathic pruritus ani respond favorably to conservative treatment. Moreover, response to specific medical therapy is almost always favorable in certain dermatologic diseases such as psoriasis, mycotic dermatitis, and contact dermatitis. When surgery is performed for anorectal disorders such as hemorrhoids and fistulas, or potentially malignant entities such as extramammary Paget's disease, the accompanying pruritus ani invariably improves as well. Only patients with chronic intractable pruritus ani are included in the current study. Methylene blue (methylthionine chloride) 0.5 percent is injected intracutaneously on the anodermal and perianal skin. With one treatment, long-term cure has been observed.
大多数特发性肛门瘙痒症患者对保守治疗反应良好。此外，对于某些皮肤病，如银屑病、霉菌性皮炎和接触性皮炎，特定的药物治疗几乎总是有效。当对痔疮和肛瘘等肛肠疾病或乳腺外佩吉特病等潜在恶性病变进行手术时，伴随的肛门瘙痒症也总是会改善。本研究仅纳入慢性顽固性肛门瘙痒症患者。将0.5%的亚甲蓝（氯化亚甲硫堇）皮内注射到肛门皮肤和肛周皮肤上。经过一次治疗，已观察到长期治愈效果。
