Jansen J B, de Jong A J, Singer M V, Niebel W, Rovati L C, Lamers C B
Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
Dig Dis Sci. 1990 Sep;35(9):1073-7. doi: 10.1007/BF01537577.
This study was undertaken to delineate the role of cholecystokinin (CCK) in bombesin- and meal-stimulated pancreatic polypeptide (PP) secretion in seven conscious dogs by studying: (1) the stimulatory effect of similar plasma levels of CCK induced by a meal and infusions of bombesin and the synthetic CCK analog cerulein on plasma PP, and (2) the inhibition of PP secretion by the CCK-receptor antagonist CR-1409 during these three stimuli. The stimulation of PP secretion during bombesin (11.0 +/- 1.6 nM/hr) and after the meal (8.9 +/- 2.0 nM/hr) were significantly (P less than 0.05) greater than during infusion of the CCK analog cerulein (2.7 +/- 0.4 nM/hr). CR-1409 significantly inhibited the bombesin- and meal-stimulated PP secretion to 2.0 +/- 0.4 nM/hr (81%; P less than 0.05) and 3.1 +/- 1.2 nM/hr (47%; P less than 0.05), respectively, while the cerulein-stimulated PP release was almost abolished to 0.2 +/- 0.1 nM/hr (93%; P less than 0.05) by the drug. These findings point to an important role for CCK in the regulation of bombesin- and meal-stimulated PP secretion.
本研究旨在通过以下方式阐明胆囊收缩素（CCK）在七只清醒犬中对蛙皮素和进食刺激的胰多肽（PP）分泌中的作用：（1）研究进食以及输注蛙皮素和合成CCK类似物雨蛙肽所诱导的相似血浆水平的CCK对血浆PP的刺激作用；（2）在这三种刺激过程中，CCK受体拮抗剂CR-1409对PP分泌的抑制作用。蛙皮素刺激期间（11.0±1.6 nM/小时）和进食后（8.9±2.0 nM/小时）PP分泌的增加显著（P<0.05）大于输注CCK类似物雨蛙肽期间（2.7±0.4 nM/小时）。CR-1409分别将蛙皮素和进食刺激的PP分泌显著抑制至2.0±0.4 nM/小时（81%；P<0.05）和3.1±1.2 nM/小时（47%；P<0.05），而该药物几乎完全抑制了雨蛙肽刺激的PP释放，使其降至0.2±0.1 nM/小时（93%；P<0.05）。这些发现表明CCK在调节蛙皮素和进食刺激的PP分泌中起重要作用。
