Wang Gang-Qiang, Wei Kun, Li Zheng-Hui, Feng Tao, Ding Jian-Hai, Wang Qiu-An, Liu Ji-Kai
a College of Chemistry and Chemical Engineering, Hunan University , Changsha , 410082 , China.
J Asian Nat Prod Res. 2013 Sep;15(9):950-5. doi: 10.1080/10286020.2013.824429. Epub 2013 Aug 5.
Three new compounds, vibranether (1), myrrhlalkyldiol (2), vibralactone H (3), together with three known compounds, 2-methyl-6-p-tolylheptane-2,3-diol (4), 2-hydroxy-2-methyl-6-p-tolylheptan-3-one (5), and vibralactone (6), were isolated from the cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic evidences (1D and 2D NMR, HRMS, UV, and IR data), chemical methods, and the literature data. The new compounds displayed no significant cytotoxicities against five human cancer cell lines (IC50>40 μM).
从担子菌 Vibrantherum vibrans 的培养物中分离出三种新化合物，即振动醚（1）、没药烷基二醇（2）、振动内酯 H（3），以及三种已知化合物，2-甲基-6-对甲苯基庚烷-2,3-二醇（4）、2-羟基-2-甲基-6-对甲苯基庚烷-3-酮（5）和振动内酯（6）。它们的结构是根据光谱证据（一维和二维核磁共振、高分辨质谱、紫外和红外数据）、化学方法以及文献数据确定的。这些新化合物对五种人类癌细胞系没有显著的细胞毒性（半数抑制浓度>40 μM）。
