1 Aging and Health Research Center, National Yang Ming University , Taipei, Taiwan .
Rejuvenation Res. 2013 Dec;16(6):453-9. doi: 10.1089/rej.2013.1442.
The main aim of this study was to explore the association between skeletal muscle mass and muscle function by three different measures of bioactive testosterone, as well as dehydroepiandrosterone sulfate (DHEA-S) among men and women aged 50 years and older in Taiwan to facilitate further investigations of sarcopenia and androgen profile.
The data of 532 participants (mean age 64.6±9.5 years; male, 53.0%) recruited from the I-Lan Longitudinal Aging Study was retrieved for analysis. Appendicular muscle mass, grip strength, and walking speed were stratified into quartiles in both genders to explore their associations with different hormones measures.
Among three different bioactive testosterone measures, the free androgen index had significant positive association with muscle mass (p both <0.001) and muscle strength in both genders (p<0.001 in men and p=0.03 in women), whereas free testosterone and bioavailable testosterone displayed similar correlations only in the skeletal muscle mass of woman (p both <0.001) and muscle strength of men (p=0.007, p=0.002, respectively). Serum levels of DHEA-S were correlated positively with skeletal muscle mass in men (p=0.013) and women aged 65 years and older (p=0.004) and handgrip strength in both genders (p<0.001 in men and p=0.009 in women). None of the bioactive testosterone measurements was associated with walking speed, whereas DHEA-S was significantly positively correlated with gait speed in both genders (p both=0.001).
In conclusion, the free androgen index increased remarkably along with muscle mass and muscle strength among men and women aged 50 years and older. Moreover, DHEA-S was positively associated with muscle mass in men and older women and muscle strength in both sexes, and was also associated with aging and gait speed in both genders.
本研究的主要目的是探讨生物活性睾酮的三种不同测量方法与肌肉功能之间的关系，以及去氢表雄酮硫酸盐（DHEA-S）与台湾 50 岁及以上男女之间的关系，以促进对肌肉减少症和雄激素状况的进一步研究。
从宜兰纵向老龄化研究中检索了 532 名参与者（平均年龄 64.6±9.5 岁；男性占 53.0%）的数据进行分析。在两性中，将四肢肌肉量、握力和步行速度分为四分位，以探讨它们与不同激素测量值的关系。
在三种不同的生物活性睾酮测量方法中，游离雄激素指数与肌肉量（均<0.001）和两性的肌肉力量（男性均<0.001，女性为 p=0.03）均呈显著正相关，而游离睾酮和生物可利用睾酮仅在女性的骨骼肌量（均<0.001）和男性的肌肉力量（分别为 p=0.007、p=0.002）方面显示出相似的相关性。DHEA-S 血清水平与男性的骨骼肌量（p=0.013）和 65 岁及以上女性（p=0.004）以及两性的握力呈正相关（男性均<0.001，女性为 p=0.009）。在两性中，生物活性睾酮测量均与步行速度无关，而 DHEA-S 与两性的步态速度呈显著正相关（均为 p=0.001）。
综上所述，游离雄激素指数随着男性和女性 50 岁及以上人群的肌肉量和肌肉力量的增加而显著增加。此外，DHEA-S 与男性和老年女性的肌肉量以及两性的肌肉力量呈正相关，与两性的衰老和步态速度也呈正相关。
