Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan.
J Am Med Dir Assoc. 2013 Jul;14(7):528.e1-7. doi: 10.1016/j.jamda.2013.03.019. Epub 2013 May 10.
To compare clinical characteristics of sarcopenia defined by the International Working Group on Sarcopenia (IWGS) and European Working Group on Sarcopenia in Older People (EWGSOP) criteria among older people in Taiwan.
A prospective population-based community study.
I-Lan County of Taiwan.
A total of 100 young healthy volunteers and 408 elderly people.
None.
Anthropometry, skeletal muscle mass measured by dual x-ray absorptiometry, relative appendicular skeletal muscle index (RASM), percentage skeletal muscle index (SMI), 6-meter walking speed, and handgrip strength.
The prevalence of sarcopenia was 5.8% to 14.9% in men and 4.1% to 16.6% in women according to IWGS and EWGSOP criteria by using RASM or SMI as the muscle mass indices. The agreement of sarcopenia diagnosed by IWGS and EWGSOP criteria was only fair by using either RASM or SMI (kappa = 0.448 by RASM, kappa = 0.471 by SMI). The prevalence of sarcopenia was lower by the IWGS definition than the EWGSOP definition, but it was remarkably lower by using RASM than SMI in both criteria. Overall, sarcopenic individuals defined by SMI were older, had a higher BMI but similar total skeletal muscle mass, and had poorer muscle strength and physical performance than nonsarcopenic individuals. However, by using RASM, sarcopenic individuals had less total skeletal muscle mass but similar BMI than nonsarcopenic individuals. Multivariable logistic regression showed that age was the strongest associative factor for sarcopenia in both IWGS and EWGSOP criteria. Obesity played a neutral role in sarcopenia when it is defined by using RASM, but significantly increased the risk of sarcopenia in both criteria by using SMI.
The agreement of sarcopenia defined by IWGS and EWGSOP was only fair, and the prevalence varied largely by using different skeletal muscle mass indices. Proper selections for cutoff values of handgrip strength, walking speed, and skeletal muscle indices with full considerations of gender and ethnic differences were of critical importance to reach the universal diagnostic criteria for sarcopenia internationally.
比较国际肌少症工作组（IWGS）和欧洲老年人肌少症工作组（EWGSOP）定义的肌少症在台湾老年人中的临床特征。
一项前瞻性、基于人群的社区研究。
台湾宜兰县。
共纳入 100 名年轻健康志愿者和 408 名老年人。
无。
人体测量学、双能 X 线吸收法测量骨骼肌质量、相对四肢骨骼肌指数（RASM）、骨骼肌指数百分比（SMI）、6 米步行速度和握力。
根据 IWGS 和 EWGSOP 标准，使用 RASM 或 SMI 作为肌肉质量指数，男性肌少症的患病率为 5.8%至 14.9%，女性为 4.1%至 16.6%。使用 RASM 或 SMI 时，IWGS 和 EWGSOP 标准诊断的肌少症的一致性仅为中等（RASM 时的 κ 值为 0.448，SMI 时的 κ 值为 0.471）。与 EWGSOP 标准相比，IWGS 标准下的肌少症患病率较低，但使用 RASM 时比 SMI 显著更低。总体而言，与非肌少症者相比，SMI 定义的肌少症者年龄更大、BMI 更高但总骨骼肌质量相似，肌肉力量和身体机能更差。然而，使用 RASM 时，与非肌少症者相比，肌少症者的总骨骼肌质量更少但 BMI 相似。多变量 logistic 回归显示，年龄是 IWGS 和 EWGSOP 标准中肌少症最强的关联因素。肥胖在使用 RASM 定义肌少症时起中性作用，但在使用 SMI 时显著增加了肌少症的风险。
IWGS 和 EWGSOP 定义的肌少症的一致性仅为中等，且使用不同骨骼肌质量指数时患病率差异很大。充分考虑性别和种族差异，正确选择握力、步行速度和骨骼肌指数的截断值对于在国际上达到肌少症的通用诊断标准至关重要。
