Yan Ren-Yi, Liu Hong-Liang, Zhang Jian-Yong, Yang Bin
a Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700 , China.
J Asian Nat Prod Res. 2014;16(4):400-5. doi: 10.1080/10286020.2013.823952. Epub 2013 Aug 5.
A new phenolic glycoside, syringic acid 4-O-β-D-glucopyranosyl-(1 → 5)-α-L-rhamnopyranoside (1), together with 12 known compounds consisting of eight phenolic glycosides (2-9), two phenolic acids (10 and 11), and two norsesquiterpenoids (12 and 13), was isolated from the methanol extract of the bark of Magnolia officinalis. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 1-11 were evaluated for their inhibitory activities against fructose-1,6-bisphosphatase, aldose reductase, lipase, dipeptidyl peptidase-IV, α-glucosidase, and three cancer cell lines. However, all the compounds showed weak or no activities in these tests.
从厚朴树皮的甲醇提取物中分离出一种新的酚苷，紫丁香酸4 - O - β - D - 吡喃葡萄糖基 - (1→5) - α - L - 鼠李吡喃糖苷(1)，以及由8种酚苷(2 - 9)、2种酚酸(10和11)和2种降倍半萜(12和13)组成的12种已知化合物。通过光谱分析和化学方法阐明了它们的结构。对化合物1 - 11进行了果糖 - 1,6 - 二磷酸酶、醛糖还原酶、脂肪酶、二肽基肽酶 - IV、α - 葡萄糖苷酶以及三种癌细胞系的抑制活性评价。然而，所有化合物在这些测试中均表现出较弱的活性或无活性。
