一种来自胡桃楸的新酚苷。
A new phenolic glycoside from Juglans mandshurica.
作者信息
Yao Dalei, Jin Mei, Zhang Changhao, Luo Jie, Li Ren, Zheng Mingshan, Cui Jiongmo, Li Gao
机构信息
a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules , Ministry of Education, Yanbian University College of Pharmacy , Yanji 133002 , China.
出版信息
Nat Prod Res. 2014;28(13):998-1002. doi: 10.1080/14786419.2014.902946. Epub 2014 Apr 4.
A new phenolic glycoside, 6-O-(4'-hydroxy-3',5'-dimethoxybenzoyl)-d-glucopyranose (4), and nine known compounds (1-3 and 5-10) were isolated from Juglans mandshurica Maxim. Compound structures were elucidated by NMR, HR-ESI-MS and acid hydrolysis. Compounds 5 and 6 are reported from this genus for the first time. Among compounds 1-10, only 1 exhibited cytotoxicity against MGC-803, A549, K562, JAR, HeLa, CaSKi and SiHa cell lines (IC50: 2.0, 5.3, 2.3, 6.9, 4.0, 6.6 and 2.7 μM, respectively).
从胡桃楸中分离得到一种新的酚苷，6-O-(4'-羟基-3',5'-二甲氧基苯甲酰基)-d-吡喃葡萄糖(4)，以及9个已知化合物(1-3和5-10)。通过核磁共振、高分辨电喷雾电离质谱和酸水解对化合物结构进行了鉴定。化合物5和6首次从该属植物中报道。在化合物1-10中，只有1对MGC-803、A549、K562、JAR、HeLa、CaSKi和SiHa细胞系表现出细胞毒性(IC50分别为2.0、5.3、2.3、6.9、4.0、6.6和2.7 μM)。
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