从北细辛中分离得到一种具有抗炎活性的新型四氢呋喃型木脂素。
A new tetrahydrofuran-type lignan with anti-inflammatory activity from Asarum heterotropoides Fr. Schmidt var. mandshuricum.
作者信息
Huang Jian, Wang Hui-Qing, Zhang Cui, Li Guo-Yu, Lin Rui-Chao, Wang Jin-Hui
机构信息
a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.
出版信息
J Asian Nat Prod Res. 2014;16(4):387-92. doi: 10.1080/10286020.2013.820713. Epub 2013 Aug 5.
A new tetrahydrofuran-type lignan, episesaminone (1), was isolated from Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. Its structure was established by spectroscopic techniques (HR-MS, 1D NMR, 2D NMR, and circular dichroism). The anti-inflammatory activity in RAW 264.7 macrophages was carried out on 1 and other eight known compounds, the epimer of 1 (2) and seven known furofurans-type lignan (3-9) obtained from A. heterotropoides Fr. Schmidt var. mandshuricum. Compounds 1, 2, 3, 4, 5, 7, and 9 showed significant anti-inflammatory activity, particularly 50 μM compound 3 inhibited 69.2% NO production compared with the lipopolysaccharide group.
从北细辛（Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag.）中分离得到一种新的四氢呋喃型木脂素，表芝麻素酮（1）。通过光谱技术（高分辨质谱、一维核磁共振、二维核磁共振和圆二色光谱）确定了其结构。对化合物1及其他8种已知化合物（1的差向异构体（2）以及从北细辛中获得的7种已知呋喃呋喃型木脂素（3 - 9））进行了RAW 264.7巨噬细胞中的抗炎活性研究。化合物1、2、3、4、5、7和9表现出显著的抗炎活性，特别是50 μM的化合物3与脂多糖组相比抑制了69.2%的一氧化氮生成。
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