KM-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
Molecules. 2013 Dec 23;19(1):122-38. doi: 10.3390/molecules19010122.
A new tetrahydrofuran lignan, (7S,8R,7'S,8'S)-3-methoxy-3',4'-methylenedioxy-7,9'-epoxylignane-4,7',9-triol (1), and 21 known compounds 2-22 were isolated from the roots of Asiasarum heterotropoides by chromatographic separation methods. The structures of all compounds 1-22 were elucidated by spectroscopic analysis including 1D- and 2D-NMR. Fourteen of these compounds (1-3, 7, 10, 12-17, 19, 21, and 22) were isolated from this species in this study for the first time. All of the isolates were evaluated for their anticancer activities using in vitro assays. Among the 22 tested compounds, two (compounds 5 and 7) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity.
从Asiasarum heterotropoides 的根部通过色谱分离方法分离得到一种新的四氢呋喃木脂素，（7S,8R,7'S,8'S）-3-甲氧基-3',4'-亚甲二氧基-7,9'-环氧木脂烷-4,7',9-三醇（1）和 21 种已知化合物 2-22。通过包括 1D-和 2D-NMR 的光谱分析阐明了所有化合物 1-22 的结构。在这项研究中，其中 14 种化合物（1-3、7、10、12-17、19、21 和 22）是从该种植物中首次分离得到的。所有分离物均通过体外测定评估其抗癌活性。在 22 种测试化合物中，有两种（化合物 5 和 7）诱导了 NO 产生、FOXP3 表达和 HIF-1α转录活性的下调。
