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新西兰女性可改变生活方式因素与乳腺癌的人群归因风险。

Population attributable risks for modifiable lifestyle factors and breast cancer in New Zealand women.

机构信息

Department of Applied Science and Allied Health, Christchurch Polytechnic Institute of Technology, Christchurch, New Zealand.

出版信息

Intern Med J. 2013 Nov;43(11):1198-204. doi: 10.1111/imj.12256.

Abstract

BACKGROUND

Breast cancer is the most commonly diagnosed invasive cancer in New Zealand women and modifiable lifestyle risk factors may contribute to this.

AIM

To estimate population attributable risks for modifiable lifestyle factors and breast cancer in New Zealand.

METHODS

Estimates of the magnitude of the impact of modifiable lifestyle risk factors for breast cancer (relative risks and odds ratios obtained from published epidemiological studies) and the prevalence of exposure in New Zealand were used to calculate the population attributable risk percent (PAR%) for each risk factor. The PAR% show the relative importance of these considered risk factors and give an indication of the potential impact of reducing the prevalence of these lifestyle risk factors on the incidence of breast cancer in New Zealand.

RESULTS

Six modifiable lifestyle factors were identified for breast cancer. These were obesity, lack of physical activity, high alcohol intake, oral contraceptive use, hormone replacement therapy (HRT) and delayed first birth. The PAR% for these risk factors ranged from 1% for delayed first birth to 10% for obesity (16% for Maori women and 17% for Pacific women).

CONCLUSIONS

The most important primary preventive strategies to reduce the risk of breast cancer in New Zealand are lifestyle changes to reduce obesity, promoting regular physical activity (which may in turn reduce the prevalence of obesity), reducing HRT use and avoiding high alcohol intake. Strategies that encourage regular physical activity and reduce obesity could also have other benefits, such as reduced risks of cardiovascular disease and diabetes.

摘要

背景

乳腺癌是新西兰女性最常见的侵袭性癌症,可改变的生活方式危险因素可能对此有影响。

目的

估计可改变的生活方式危险因素对新西兰乳腺癌的人群归因风险。

方法

使用可改变的生活方式危险因素(从已发表的流行病学研究中获得的相对风险和比值比)对乳腺癌的影响程度的估计值以及新西兰的暴露流行率来计算每个危险因素的人群归因风险百分比(PAR%)。PAR% 显示了这些被认为的危险因素的相对重要性,并表明降低这些生活方式危险因素的流行率对新西兰乳腺癌发病率的潜在影响。

结果

确定了 6 种可改变的生活方式因素与乳腺癌有关。这些因素包括肥胖、缺乏身体活动、大量饮酒、口服避孕药的使用、激素替代疗法(HRT)和首次生育时间延迟。这些危险因素的 PAR% 范围从首次生育时间延迟的 1%到肥胖的 10%(毛利族妇女为 16%,太平洋岛民妇女为 17%)。

结论

在新西兰降低乳腺癌风险的最重要的一级预防策略是改变生活方式以减少肥胖,促进有规律的身体活动(这反过来可能降低肥胖的流行率),减少 HRT 的使用和避免大量饮酒。鼓励有规律的身体活动和减少肥胖的策略也可能有其他好处,如降低心血管疾病和糖尿病的风险。

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