Wang Yu-Chiao, Lin Ching-Hung, Huang Shih-Pei, Chen Mingchih, Lee Tian-Shyug
Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Department of Medical Oncology, National Taiwan University Cancer Center Hospital, Taipei 10016, Taiwan.
Cancers (Basel). 2022 Feb 3;14(3):788. doi: 10.3390/cancers14030788.
The incidence of female BC among the Eastern and Southeastern Asian populations has gradually increased in recent years. However, epidemiological studies on the relationship between a sedentary lifestyle and female BC are insufficient. In order to determine the association between this lifestyle and the incidence of female BC, we conducted a population-based cohort study on women in Taiwan.
We followed a prospective cohort of 5879 women aged 30 years and over enrolled in the 2001 National Health Interview Survey (NHIS), who developed female BC over a period of 72,453 person years, and we estimated the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) using the Cox proportional hazards model.
RFs associated with female BC incidence included parity (adjusted HR = 0.63; 95% CI: 0.44-0.91), body mass index (adjusted HR = 1.34; 95% CI: 1.04-1.71), and ≥3 h/day spent sitting (adjusted HR = 1.89; 95% CI: 1.08-3.32). The incidence of female BC in participants who sat for ≥3 h/day and consumed sugary drinks was 2.5 times greater than that in those who sat for <3 h/day and did not consume sugary drinks (adjusted HR = 2.51; 95% CI: 1.01-6.23).
The findings of this study indicate that sedentary behavior and sugary drink intake may increase the risk of developing female BC. These are modifiable RFs; therefore, a healthy lifestyle and diet can reduce the incidence of female BC.
近年来，东亚和东南亚人群中女性乳腺癌的发病率逐渐上升。然而，关于久坐不动的生活方式与女性乳腺癌之间关系的流行病学研究并不充分。为了确定这种生活方式与女性乳腺癌发病率之间的关联，我们对台湾女性进行了一项基于人群的队列研究。
我们追踪了2001年全国健康访谈调查（NHIS）中纳入的5879名30岁及以上的女性前瞻性队列，这些女性在72453人年的时间里患了女性乳腺癌，我们使用Cox比例风险模型估计风险比（HRs）和相应的95%置信区间（CIs）。
与女性乳腺癌发病率相关的危险因素包括生育状况（调整后的HR = 0.63；95% CI：0.44 - 0.91）、体重指数（调整后的HR = 1.34；95% CI：1.04 - 1.71）以及每天久坐≥3小时（调整后的HR = 1.89；95% CI：1.08 - 3.32）。每天久坐≥3小时且饮用含糖饮料的参与者中女性乳腺癌的发病率是每天久坐<3小时且不饮用含糖饮料的参与者的2.5倍（调整后的HR = 2.51；95% CI：1.01 - 6.23）。
本研究结果表明，久坐行为和饮用含糖饮料可能会增加患女性乳腺癌的风险。这些是可改变的危险因素；因此，健康的生活方式和饮食可以降低女性乳腺癌的发病率。
