Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):3697-703. doi: 10.1016/j.msec.2013.04.056. Epub 2013 May 4.
In this study, we successfully prepared a novel "sheet-shaped" chitosan hydrogel for wound healing consisting of both PEG-g-chitosan and a crosslinkable polymeric micelle. The study's findings clarify that the PEG modification percentage (PMP) of PEG-g-chitosan increased proportionally as the weight ratio of PEG/chitosan increased. Furthermore, the positive second virial coefficient of PEG-g-chitosans from a Debye plot strongly suggests that the PEG modification greatly improved the solubility of the water-insoluble chitosan. Finally, the "sheet-shaped" "flexible" hydrogel formed by mixing solutions containing either PEG-g-chitosan with moderate PMP or polymeric micelles exhibited the highest storage modulus. The sheet itself exhibited an attractive feature insofar as polymeric micelles, which can act as drug containers facilitating the incorporation and the gradual release of drugs, are covalently immobilized in the polymeric network of the hydrogel. The results obtained in the present study show that the hybrid PEG-g-chitosan hydrogel containing crosslinkable polymeric micelles has the potential to address the need for novel functional biomaterials.
在这项研究中，我们成功制备了一种新型的“片状”壳聚糖水凝胶，用于伤口愈合，由 PEG- g -壳聚糖和可交联的聚合物胶束组成。研究结果表明，PEG- g -壳聚糖的 PEG 修饰百分比（PMP）随着 PEG/壳聚糖重量比的增加而成比例增加。此外，从 Debye 图得出的 PEG- g -壳聚糖的正二次维里系数强烈表明，PEG 修饰极大地提高了水不溶性壳聚糖的溶解度。最后，混合含有中等 PMP 的 PEG- g -壳聚糖或聚合物胶束的溶液形成的“片状”“柔韧”水凝胶表现出最高的储能模量。薄片本身具有吸引力，因为聚合物胶束可以作为药物容器，促进药物的掺入和逐渐释放，并通过共价键固定在水凝胶的聚合物网络中。本研究的结果表明，含有可交联聚合物胶束的混合 PEG- g -壳聚糖水凝胶具有满足新型功能生物材料需求的潜力。
