Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Colloids Surf B Biointerfaces. 2018 Mar 1;163:257-265. doi: 10.1016/j.colsurfb.2017.12.054. Epub 2017 Dec 30.
We prepared the "sheet-type hydrogel" (gel sheet), a sheet consisting of PEG-grafted chitosan and cross-linkable polymeric micelles, that were expected to be used for wound healing. We optimized the PEG-modification process, evaluated the strain-dependence of the gel's properties to obtain flexible gel sheets, and evaluated the drug-release properties of the gel sheets. Finally, we succeeded in observing that the release of the antibiotic tetracycline (TET) from the gel sheet in which TET existed only in the cross-linkers was lower than the release of TET from the sheet in which TET was dispersed in the polymer networks. Our research demonstrates that the strategy of incorporating drug carriers into gel sheets might benefit the construction of biomaterials with controllable drug-release properties.
我们制备了“片状水凝胶”（凝胶片），这是一种由接枝了聚乙二醇的壳聚糖和可交联的聚合物胶束组成的薄片，预计可用于伤口愈合。我们优化了 PEG 修饰过程，评估了凝胶性质的应变依赖性，以获得具有柔韧性的凝胶片，并评估了凝胶片的药物释放性质。最后，我们成功地观察到，仅在交联剂中存在四环素（TET）的凝胶片中 TET 的释放低于在聚合物网络中分散 TET 的片材中 TET 的释放。我们的研究表明，将药物载体纳入凝胶片的策略可能有利于构建具有可控药物释放性能的生物材料。
