UPC - Universitat Politècnica de Catalunya, Barcelona Tech, INTEXTER - Institut d'Investigació Tèxtil i Cooperació Industrial de Terrassa, Colom 15, Zip Code 08222, Terrassa, Spain.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4002-8. doi: 10.1016/j.msec.2013.05.034. Epub 2013 May 25.
The primary advantages of electrospun membranes include the ability to obtain very thin fibers that are on the order of magnitude of several nanometers with a considerable superficial area and the possibility for these membranes to be manipulated and processed for many different applications. The purpose of this study is to evaluate and quantify the transport mechanisms that control the release of drugs from polymer-based sandwich membranes produced using the electrospinning processes. These electrospun membranes were composed of poly(lactic acid) (PLA) because it is one of the most promising biodegradable polymers due to its mechanical properties, thermoplastic processability and biological properties, such as its biocompatibility and biodegradability. The transport mechanism that controls the drug delivery was evaluated via the release kinetics of a bioactive agent in physiological serum, which was used as a corporal fluid simulation. To describe the delivery process, mathematical models, such as the Power Law, the classical Higuchi equation and an approach to Fick's Second Law were used. Using the applied mathematical models, it is possible to conclude that control over the release of the drug is significantly dependent on the thickness of the membrane rather than the concentration of the drug.
静电纺丝膜的主要优点包括能够获得非常细的纤维，其量级为几纳米，具有相当大的比表面积，并且这些膜可以进行处理和加工，适用于许多不同的应用。本研究的目的是评估和量化控制药物从使用静电纺丝工艺生产的聚合物三明治膜中释放的传输机制。这些静电纺丝膜由聚乳酸（PLA）组成，因为它是最有前途的可生物降解聚合物之一，具有机械性能、热塑性加工性和生物特性，如生物相容性和可降解性。通过在生理血清中释放生物活性剂的释放动力学来评估控制药物输送的传输机制，生理血清被用作体液模拟。为了描述传递过程，使用了数学模型，如幂律、经典 Higuchi 方程和对 Fick 第二定律的一种方法。通过应用数学模型，可以得出结论，药物释放的控制在很大程度上取决于膜的厚度，而不是药物的浓度。
