INSA de Rennes, Laboratoire Chimie-Métallurgie, UMR CNRS 6226 Institut des Sciences Chimiques de Rennes, 20 avenue des Buttes de Coësmes, 35708 Rennes Cedex 7, France.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4173-82. doi: 10.1016/j.msec.2013.06.008. Epub 2013 Jun 13.
In this study, a superelastic Ni-free Ti-based biomedical alloy was treated in surface by the implantation of nitrogen ions for the first time. The N-implanted surface was characterized by X-ray diffraction, X-ray photoelectron spectroscopy, and secondary ion mass spectroscopy, and the superficial mechanical properties were evaluated by nano-indentation and by ball-on-disk tribological tests. To investigate the biocompatibility, the corrosion resistance of the N-implanted Ti alloy was evaluated in simulated body fluids (SBF) complemented by in-vitro cytocompatibility tests on human fetal osteoblasts. After implantation, surface analysis methods revealed the formation of a titanium-based nitride on the substrate surface. Consequently, an increase in superficial hardness and a significant reduction of friction coefficient were observed compared to the non-implanted sample. Also, a better corrosion resistance and a significant decrease in ion release rates have been obtained. Cell culture experiments indicated that the cytocompatibility of the N-implanted Ti alloy was superior to that of the corresponding non-treated sample. Thus, this new functional N-implanted titanium-based superelastic alloy presents the optimized properties that are required for various medical devices: superelasticity, high superficial mechanical properties, high corrosion resistance and excellent cytocompatibility.
本研究首次采用氮离子注入法对一种无镍的超弹性 Ti 基生物医学合金进行表面处理。采用 X 射线衍射、X 射线光电子能谱和二次离子质谱对 N 注入表面进行了表征，并通过纳米压痕和球盘摩擦试验评估了表面力学性能。为了研究生物相容性，在补充了人胎成骨细胞体外细胞相容性试验的模拟体液（SBF）中评估了 N 注入 Ti 合金的耐腐蚀性。注入后，表面分析方法表明在基底表面形成了一种基于钛的氮化物。因此，与未注入样品相比，表面硬度显著提高，摩擦系数显著降低。此外，还获得了更好的耐腐蚀性和离子释放率的显著降低。细胞培养实验表明，N 注入 Ti 合金的细胞相容性优于相应的未处理样品。因此，这种新的功能性 N 注入钛基超弹性合金具有各种医疗器械所需的优化性能：超弹性、高表面力学性能、高耐腐蚀性和优异的细胞相容性。
