Faculty of Chemistry, Jagiellonian University, ul. Ingardena 3, PL-30060 Krakow, Poland.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4221-7. doi: 10.1016/j.msec.2013.06.014. Epub 2013 Jun 20.
The effect of oxygen plasma treatment (t=0.1-60 min, pO2=0.2 mbar, P=50 W) of parylene C implant surface coating was investigated in order to check its influence on morphology (SEM, AFM observations), chemical composition (XPS analysis), hydrophilicity (contact angle measurements) and biocompatibility (MG-63 cell line and Staphylococcus aureus 24167 DSM adhesion screening). The modification procedure leads to oxygen insertion (up to 20 at.%) into the polymer matrix and together with surface topography changes has a dramatic impact on wettability (change of contact angle from θ=78±2 to θ=33±1.9 for unmodified and 60 min treated sample, respectively). As a result, the hydrophilic surface of modified parylene C promotes MG-63 cells growth and at the same time does not influence S. aureus adhesion. The obtained results clearly show that the plasma treatment of parylene C surface provides suitable polar groups (C=O, C-O, O-C=O, C-O-O and O-C(O)-O) for further development of the coating functionality.
为了研究其对形态（SEM、AFM 观察）、化学成分（XPS 分析）、亲水性（接触角测量）和生物相容性（MG-63 细胞系和金黄色葡萄球菌 24167DSM 粘附筛选）的影响，我们对聚对二甲苯 C 植入物表面涂层进行了氧等离子体处理（t=0.1-60min，pO2=0.2 毫巴，P=50W）。修饰过程导致聚合物基质中插入氧（高达 20at.%），并且与表面形貌变化一起对润湿性有显著影响（未处理和处理 60min 后样品的接触角分别从θ=78±2变为θ=33±1.9）。结果表明，改性聚对二甲苯 C 的亲水表面促进了 MG-63 细胞的生长，同时不影响金黄色葡萄球菌的粘附。所得结果清楚地表明，聚对二甲苯 C 表面的等离子体处理为进一步发展涂层功能提供了合适的极性基团（C=O、C-O、O-C=O、C-O-O 和 O-C（O）-O）。
