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Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer.杂合性丢失（LOH）图谱——口腔癌进展的有效风险预测因子。
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The BATTLE to personalize lung cancer prevention through reverse migration.通过反向迁移实现肺癌个体化预防的斗争。
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口腔癌前病变：早期检测与化学预防的作用

Oral premalignancy: the roles of early detection and chemoprevention.

作者信息

Foy Jean-Philippe, Bertolus Chloé, William William N, Saintigny Pierre

机构信息

Department of Maxillofacial Surgery, Pitié-Salpêtrière Hospital, 47-83 boulevard de l' Hôpital, Paris 75013, France.

出版信息

Otolaryngol Clin North Am. 2013 Aug;46(4):579-97. doi: 10.1016/j.otc.2013.04.010. Epub 2013 May 25.

DOI:10.1016/j.otc.2013.04.010
PMID:23910471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3734384/
Abstract

Premalignancy and chemoprevention studies in head and neck cancer typically focus on the oral cavity. Avoiding or cessation of alcohol and smoking, early detection of potentially malignant disorders or cancer, and early detection of recurrent and/or second primary tumor form the basis of prevention of oral cancer. Analysis of tissue prospectively collected in evaluation of retinoids for chemoprevention trials allowed identification of molecular biomarkers of risk to develop oral cancer, loss of heterozygosity being the most validated one. Improving risk assessment and identification of new targets for chemoprevention represent the main challenges in this field.

摘要

头颈部癌症的癌前病变和化学预防研究通常聚焦于口腔。避免饮酒和吸烟或戒烟、早期发现潜在恶性疾病或癌症，以及早期发现复发性和/或第二原发性肿瘤，构成了口腔癌预防的基础。对在维甲酸化学预防试验评估中前瞻性收集的组织进行分析，有助于识别发生口腔癌风险的分子生物标志物，杂合性缺失是最得到验证的一种。改善风险评估和识别化学预防的新靶点是该领域的主要挑战。