Liver Unit, Freeman Hospital, Newcastle upon Tyne Hospitals Foundation NHS Trust, Newcastle upon Tyne, UK.
J Viral Hepat. 2013 Sep;20(9):638-44. doi: 10.1111/jvh.12084. Epub 2013 Mar 12.
Chronic infection with the hepatitis B virus (HBV) is a frequent cause of cirrhosis and liver cancer. Targeted HBV screening is recommended by the Centre for Disease Control (CDC) and Prevention for subjects born in countries with >2% HBV prevalence. However, there are no UK guidelines. Here, we applied the (CDC) recommendations to the British-Chinese and British-South Asian community of North-East (NE) England. British-Chinese and South Asian subjects were invited to attend for HBV education and screening sessions held in community centres. Hepatitis B surface antigen (HBsAg) and hepatitis B core total antibody (HBcAb) were tested with dry blood spot tests. South Asians were also tested for hepatitis C antibody (HCVAb). A total of 1126 subjects (606 Chinese and 520 South Asian) were screened. Sixty-two (5.5%) were HBsAg positive. Ten of these reported a previous diagnosis of HBV. The prevalence of HBsAg positivity was 4.6% when previously diagnosed individuals were excluded. The HBsAg prevalence was significantly higher in the Chinese subjects compared with South Asians (8.7% VS. 1.7% P < 0.001). In Chinese subjects, HBsAg positivity was highest in subjects born in Vietnam (17.4%), followed by China (11%), Hong Kong (7.8%) and the UK (6.7%). Subjects from Pakistan had the highest HBsAg and HCV Ab prevalence in the South Asians (3.1% and 1.8%, respectively). Ten percentage of HBsAg positive patients who had follow-up assessment had active disease requiring antiviral treatment. Undiagnosed HBV infection was above the 2% threshold for screening suggested by the CDC in the British-Chinese and Pakistani community of NE England, which provides evidence for a UK HBV-targeted screening programme.
慢性乙型肝炎病毒（HBV）感染是肝硬化和肝癌的常见病因。疾病控制与预防中心（CDC）建议对乙型肝炎病毒流行率超过 2%的国家出生的人群进行 HBV 筛查。然而，英国没有相关指南。在这里，我们将（CDC）的建议应用于英格兰东北部的英国-华裔和英国-南亚社区。邀请英国华裔和南亚裔人群参加在社区中心举行的 HBV 教育和筛查会议。使用干血斑检测检测乙型肝炎表面抗原（HBsAg）和乙型肝炎核心总抗体（HBcAb）。南亚裔人群还检测丙型肝炎抗体（HCVAb）。共筛查了 1126 名受试者（606 名中国人和 520 名南亚人）。62 人（5.5%）HBsAg 阳性。其中 10 人报告了乙型肝炎病毒的既往诊断。排除既往诊断个体后，HBsAg 阳性率为 4.6%。中国人的 HBsAg 阳性率明显高于南亚人（8.7%比 1.7%，P < 0.001）。在中国人群中，HBsAg 阳性率在出生于越南的人群中最高（17.4%），其次是中国（11%）、香港（7.8%）和英国（6.7%）。南亚人中，巴基斯坦裔的 HBsAg 和 HCV Ab 阳性率最高（分别为 3.1%和 1.8%）。10%接受后续评估的 HBsAg 阳性患者患有需要抗病毒治疗的活动性疾病。未确诊的乙型肝炎病毒感染超过了疾病控制与预防中心建议的英国华裔和巴基斯坦裔人群 2%的筛查阈值，这为英国乙型肝炎病毒靶向筛查计划提供了证据。
