Orthopaedics Key Laboratory of Gansu province, Department of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
J Arthroplasty. 2013 Dec;28(10):1882-7. doi: 10.1016/j.arth.2013.06.031. Epub 2013 Aug 1.
The efficacy of periarticular multimodal drug injection (PMDI) to reduce pain after total knee or hip arthroplasty (TKA or THA) still remains controversial. Our study aimed at evaluating the efficacy of PMDI after TKA or THA. A fully recursive literature search was conducted to identify relevant randomized controlled trials. Ultimately, 21 studies were included in the analysis. Pooled results showed that the PMDI group had better pain relief, less opioid consumption, larger range of motion, and lower rates of nausea and vomiting than the placebo group. No significant difference was seen in regard to the length of hospital stay between the two groups. In conclusion, PMDI should be recommended for the pain management after TKA or THA.
关节周围多模式药物注射（PMDI）在减少全膝关节或髋关节置换术后（TKA 或 THA）疼痛方面的疗效仍存在争议。我们的研究旨在评估 TKA 或 THA 后 PMDI 的疗效。进行了全面的递归文献检索以确定相关的随机对照试验。最终，有 21 项研究纳入分析。汇总结果显示，与安慰剂组相比，PMDI 组疼痛缓解更好，阿片类药物消耗更少，活动范围更大，恶心和呕吐发生率更低。两组的住院时间无显著差异。总之，PMDI 应该被推荐用于 TKA 或 THA 后的疼痛管理。
