Lari Shahrzad M, Ghobadi Hassan, Attaran Davood, Mahmoodpour Afsoun, Shadkam Omid, Rostami Maryam
Mashhad University of Medical Sciences, COPD Research Center, School of Medicine, Mashhad, Iran.
Clin Respir J. 2014 Jan;8(1):116-23. doi: 10.1111/crj.12047. Epub 2013 Nov 5.
Chronic obstructive pulmonary disease (COPD) is one of the serious late pulmonary complications caused by sulphur mustard exposure. Health status evaluations of chemical warfare patients with COPD are important to the management of these patients. The aim of this study was to determine the efficacy of the COPD assessment test (CAT) in evaluating the health-related quality of life (HRQOL) of chemical warfare patients with COPD.
Eighty-two consecutive patients with stable COPD were enrolled in this study. All subjects were visited by one physician, and the HRQOL was evaluated by the CAT and St. George Respiratory Questionnaires (SGRQs). In addition, a standard spirometry test, 6-min walk distance test and pulse oxymetry were conducted. The severity of the COPD was determined using Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging and the body mass index, obstruction, dyspnoea and exercise (BODE) index.
The mean age of the patients was 47.30 ± 7.08 years. The mean CAT score was 26.03 ± 8.28. Thirty-five (43%) patients were in CAT stage 3. There were statistically significant correlations between the CAT and the SGRQ (r = 0.70, P = 0.001) and the BODE index (r = 0.70, P = 0.001). A statistically significant inverse correlation was found between the CAT score and the forced expiratory volume in 1 s (r = -0.30, P = 0.03).
Our results demonstrated that the CAT is a simple and valid tool for assessment of HRQOL in chemical warfare patients with COPD and can be used in clinical practice.
慢性阻塞性肺疾病（COPD）是芥子气暴露导致的严重晚期肺部并发症之一。对患有COPD的化学战患者进行健康状况评估对这些患者的管理很重要。本研究的目的是确定COPD评估测试（CAT）在评估患有COPD的化学战患者的健康相关生活质量（HRQOL）方面的有效性。
本研究纳入了82例连续的稳定期COPD患者。所有受试者均由一名医生进行访视，并通过CAT和圣乔治呼吸问卷（SGRQ）评估HRQOL。此外，还进行了标准肺量计测试、6分钟步行距离测试和脉搏血氧饱和度测定。使用慢性阻塞性肺疾病全球倡议（GOLD）分期以及体重指数、气流受限、呼吸困难和运动（BODE）指数来确定COPD的严重程度。
患者的平均年龄为47.30±7.08岁。平均CAT评分为26.03±8.28。35例（43%）患者处于CAT 3期。CAT与SGRQ（r = 0.70，P = 0.001）以及BODE指数（r = 0.70，P = 0.001）之间存在统计学显著相关性。发现CAT评分与1秒用力呼气量之间存在统计学显著负相关（r = -0.30，P = 0.03）。
我们的结果表明，CAT是评估患有COPD的化学战患者HRQOL的一种简单有效的工具，可用于临床实践。
