University of Bonn, Dietkirchenstrasse 28, 53111 Bonn, Germany.
Brain Cogn. 2013 Oct;83(1):61-71. doi: 10.1016/j.bandc.2013.06.009. Epub 2013 Jul 31.
The nogo N2 component, an anterior negative peak supposed to be generated in the anterior cingulate cortex, has been used as an indicator of conflict monitoring and response conflict in basic and clinical research. Here, we investigate the reliability and the signal-to-noise ratio (SNR) of inter-individual differences of the N2 amplitudes as well as of intra-individual standard deviations of N2 amplitudes. Effects of the number of nogo epochs, type of summary measure (peak vs. average amplitude), and filter cut-offs (1-12 Hz vs. 1-30 Hz) are investigated. A sample of N=32 participants, performed a go/nogo task. Excellent Cronbach's alpha coefficients (> or = .90) were obtained for the fronto-central average N2 amplitude at 40 nogo epochs and for the peak N2 amplitude at 60 nogo epochs. The SNR was higher for the average nogo N2 amplitude compared to the peak N2 amplitude. Split-half reliability coefficients of the intra-individual standard deviation of the nogo N2 amplitudes were at least moderate. Based on these results we provide suggestions for a reliable N2 measurement. Moreover, although intra-individual variability has often been conceived as noise the present findings support the idea that intra-individual N2 variability incorporates systematic variance.
Nogo N2 成分是前扣带皮层中产生的一个前负峰，被用作冲突监测和反应冲突的指标，在基础和临床研究中得到了广泛应用。本研究旨在探讨 N2 振幅个体间差异的可靠性和信噪比（SNR），以及 N2 振幅的个体内标准差。研究了 Nogo 时期的数量、汇总测量的类型（峰值与平均振幅）以及滤波器截止频率（1-12 Hz 与 1-30 Hz）的影响。共有 32 名参与者完成了 Go/Nogo 任务。在 40 个 Nogo 时期的额中央平均 N2 振幅和 60 个 Nogo 时期的峰值 N2 振幅的 Cronbach's alpha 系数（> =.90）均非常高。与峰值 N2 振幅相比，平均 N2 振幅的 SNR 更高。Nogo N2 振幅的个体内标准差的半分可靠性系数至少为中等。基于这些结果，我们提供了可靠的 N2 测量建议。此外，尽管个体内变异性通常被视为噪声，但本研究结果支持个体内 N2 变异性包含系统变异性的观点。
