希腊经皮冠状动脉介入治疗的急性冠状动脉综合征患者的现状管理和生活质量：抗血小板治疗观察性研究 II（APTOR II）的 12 个月结果。

Current management and quality of life of patients with acute coronary syndrome undergoing percutaneous coronary intervention in Greece: 12-Month results from antiplatelet therapy observational study II (APTOR II).

机构信息

Onassis Cardiac Surgery Centre, Kallithea, Greece.

出版信息

Hellenic J Cardiol. 2013 Jul-Aug;54(4):255-63.

Abstract

INTRODUCTION

We describe the current management of patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI) over 12 months in Greece.

METHODS

This was a prospective observational study in ACS patients undergoing PCI from September 2008 to April 2009, capturing practices over 12 months at 22 sites that enrolled 558 eligible patients.

RESULTS

A total of 351 patients suffered from unstable angina or non-ST elevation myocardial infarction (UA/ NSTEMI), while 207 patients suffered from ST-elevation myocardial infarction (STEMI). For the UA/NSTEMI group, the median age was 64 years (interquartile range: 55-73), while for the STEMI group the median age was 56 years (interquartile range: 49-66). Stents were placed in 96.4% of patients: bare-metal stents alone were placed in 19% of patients, drug-eluting stents alone in 77.5% of patients, and both types of stent in 3.5% of patients. 74% of UA/NSTEMI patients and 87% of STEMI patients received the first antiplatelet loading dose within 1 day of the episode. 76% of UA/NSTEMI patients underwent PCI within 3 days following the initial ACS symptoms, while 67% of STEMI patients underwent PCI within 1 day of the ACS symptoms. Follow-up data were available for 540 (96.8%) patients. The percentages of patients on antiplatelet therapy and on other medications at the time of hospital discharge and at 12 months post-PCI were as follows: aspirin 98%, 97%; clopidogrel 99%, 96%; statins 81%, 79%; beta-blockers 73%, 72%; calcium blockers 11%, 11%; angiotensin II receptor blockers/angiotensin-converting enzyme inhibitors 64%, 62%; proton-pump inhibitors 39%, 35%.

CONCLUSIONS

In ACS patients treated with PCI in Greece, dual antiplatelet treatment is maintained in a very high percentage through 1 year post-procedure, and drug-eluting stent use is also high.

摘要

简介

我们描述了在希腊，12 个月内行经皮冠状动脉介入治疗（PCI）的急性冠状动脉综合征（ACS）患者的当前管理情况。

方法

这是一项前瞻性观察性研究，纳入了 2008 年 9 月至 2009 年 4 月间接受 PCI 的 ACS 患者，共 558 例符合条件的患者在 22 个研究中心入组，记录了 12 个月的治疗情况。

结果

351 例患者患有不稳定型心绞痛或非 ST 段抬高型心肌梗死（UA/NSTEMI），207 例患者患有 ST 段抬高型心肌梗死（STEMI）。UA/NSTEMI 组患者的中位年龄为 64 岁（四分位间距：55-73），STEMI 组患者的中位年龄为 56 岁（四分位间距：49-66）。96.4%的患者置入了支架：单纯使用裸金属支架的患者占 19%，单纯使用药物洗脱支架的患者占 77.5%，同时使用两种支架的患者占 3.5%。74%的 UA/NSTEMI 患者和 87%的 STEMI 患者在发病后 1 天内接受了首次抗血小板负荷剂量。76%的 UA/NSTEMI 患者在初次 ACS 症状后 3 天内行 PCI，67%的 STEMI 患者在 ACS 症状后 1 天内行 PCI。540 例（96.8%）患者可获得随访数据。患者在出院时和 PCI 后 12 个月时的抗血小板治疗和其他药物的使用率如下：阿司匹林 98%，97%；氯吡格雷 99%，96%；他汀类药物 81%，79%；β受体阻滞剂 73%，72%；钙通道阻滞剂 11%，11%；血管紧张素 II 受体阻滞剂/血管紧张素转换酶抑制剂 64%，62%；质子泵抑制剂 39%，35%。