Tan Joseph, Berke Stanley
Nassau University Medical Center, East Meadow, Westbury, NY, USA.
Optom Vis Sci. 2013 Sep;90(9):e245-7; discussion 1029. doi: 10.1097/OPX.0b013e31829d8dd7.
To report, with supporting photo-documentation, cases of latanoprost-induced prostaglandin-associated periorbitopathy (PAP).
Retrospective small case series with three cases. Chart review with photo-documentation of clinical features of prostaglandin-associated periorbitopathy resulting from latanoprost use. Patients developed involution of dermatochalasia, blepharoptosis, deepening of orbital sulci, and flattening of lower eyelid bags after a mean usage period of 6 years (3 to 8 years).
Latanoprost can cause PAP, although it has a lower risk and longer latency of onset than those with bimatoprost and travoprost. Clinicians should be aware of this side effect and monitor for signs periodically. Chronic unilateral prostaglandin use may cause unfavorable asymmetry in the appearance of the periorbital area.
通过辅助照片记录，报告拉坦前列素诱导的前列腺素相关性眶周病变（PAP）病例。
回顾性小病例系列，共三例。通过图表回顾及照片记录因使用拉坦前列素导致的前列腺素相关性眶周病变的临床特征。患者在平均使用6年（3至8年）后出现皮肤松弛退缩、上睑下垂、眶沟加深和下睑眼袋变平。
拉坦前列素可导致PAP，尽管其风险低于比马前列素和曲伏前列素，且发病潜伏期更长。临床医生应意识到这种副作用并定期监测体征。长期单侧使用前列腺素可能导致眶周区域外观出现不良不对称。
