Liu X L, Yang Q F, Kong B H
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji'nan, Shandong, China.
Genet Mol Res. 2013 Jun 13;12(2):1924-33. doi: 10.4238/2013.June.13.1.
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well as the subsequent meta-analyses, remain contradictory. We investigated the association between VEGF +936C/T polymorphism and cancer risk in the Asian population. Twenty-one papers were selected from the PubMed database after a systematic search. Statistics on the frequencies of CC, CT, and TT genotypes of the VEGF +936C/T gene were collected from 8298 cases and 8053 controls. No significant associations between the VEGF +936C/T polymorphism and cancer risk were found for alleles T vs C [odd ratio (OR) = 0.99, 95% confidence interval (95%CI) = 0.93-1.05], TT vs CT/CC (OR = 1.05, 95%CI = 0.88-1.26), CC vs CT/TT (OR = 1.02, 95%CI = 0.96-1.10), and TT vs CC (OR = 1.05, 95%CI = 0.88-1.25). No significant associations were detected in the subgroup analysis by cancer type either. The VEGF +936C/T polymorphism is not associated with risk of overall cancer among Asians.
血管内皮生长因子（VEGF）是血管生成和血管通透性的最重要调节因子，参与致癌作用的各个步骤。据报道，VEGF基因的+936C/T多态性会影响VEGF蛋白水平，并与癌症易感性相关。然而，已发表研究的结果以及随后的荟萃分析仍然相互矛盾。我们调查了亚洲人群中VEGF +936C/T多态性与癌症风险之间的关联。经过系统检索，从PubMed数据库中选择了21篇论文。收集了8298例病例和8053例对照中VEGF +936C/T基因CC、CT和TT基因型的频率统计数据。在等位基因T与C [比值比（OR）= 0.99，95%置信区间（95%CI）= 0.93 - 1.05]、TT与CT/CC（OR = 1.05，95%CI = 0.88 - 1.26）、CC与CT/TT（OR = 1.02，95%CI = 0.96 - 1.10）以及TT与CC（OR = 1.05，95%CI = 0.88 - 1.25）之间，未发现VEGF +936C/T多态性与癌症风险有显著关联。在按癌症类型进行的亚组分析中也未检测到显著关联。VEGF +936C/T多态性与亚洲人总体癌症风险无关。
