Zhou Li-Ping, Luan Hong, Dong Xin-Hua, Jin Guo-Jiang, Man Dong-Liang, Shang Hong
Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang 110001, P.R. China.
Exp Ther Med. 2011 Sep;2(5):931-936. doi: 10.3892/etm.2011.278. Epub 2011 May 31.
The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase and CBM databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 software. From these data, the odds ratio (OR) with 95% confidence interval (CI) was calculated. Finally, 8 case-control studies were retrieved reporting a total of 2,131 gastrointestinal cancer patients and 2,670 controls. Meta-analysis results showed that there was no significant association between the VEGF +936C/T polymorphism and GC risk in all comparisons of the T allele vs. C allele (OR=1.08, 95% CI 0.90-1.30, P=0.42), CT+TT vs. CC (OR=1.08, 95% CI 0.87-1.34, P=0.49), TT vs. CC+CT (OR=1.14, 95% CI 0.85-1.53, P=0.37), TT vs. CC (OR=1.18, 95% CI 0.87-1.59, P=0.28) and TT vs. CT (OR=1.11, 95% CI 0.79-1.56, P=0.56). This meta-analysis confirms that there is a lack of association between the VEGF +936C/T polymorphism and GC risk.
本研究旨在通过荟萃分析确定血管内皮生长因子（VEGF）+936C/T多态性是否与胃癌（GC）易感性相关。从PubMed、Embase和CBM数据库中筛选出关于VEGF +936C/T多态性与GC风险关联的文献。由两名独立审阅者从研究中提取数据。使用RevMan 5.0.25和STATA 9.2软件进行荟萃分析。根据这些数据，计算出比值比（OR）及95%置信区间（CI）。最终，检索到8项病例对照研究，共纳入2131例胃肠道癌患者和2670例对照。荟萃分析结果显示，在所有T等位基因与C等位基因的比较中，VEGF +936C/T多态性与GC风险之间无显著关联（OR = 1.08，95% CI 0.90 - 1.30，P = 0.42），CT + TT与CC比较（OR = 1.08，95% CI 0.87 - 1.34，P = 0.49），TT与CC + CT比较（OR = 1.14，95% CI 0.85 - 1.53，P = 0.37），TT与CC比较（OR = 1.18，95% CI 0.87 - 1.59，P = 0.28）以及TT与CT比较（OR = 1.11，95% CI 0.79 - 1.56，P = 0.56）。该荟萃分析证实VEGF +936C/T多态性与GC风险之间缺乏关联。
