Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia.
BMC Neurol. 2013 Aug 5;13:103. doi: 10.1186/1471-2377-13-103.
It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.
We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.
先前的研究表明，MTHFR 基因多态性与偏头痛风险增加相关，尤其是有先兆的偏头痛。MTHFR 基因第 677 位胞嘧啶被胸腺嘧啶替代会导致蛋白质形成热不稳定形式，并导致高同型半胱氨酸血症，增加偏头痛的发生概率。本研究旨在确定 MTHFR 基因中的 C677T 替换是否会影响疾病的特定症状。
我们分析了 83 例偏头痛患者（根据 ICHD-II（2003）分为有先兆偏头痛（MA）19 例和无先兆偏头痛（MO）64 例）的临床和电生理特征，同时考虑了他们 MTHFR C677T 变体的基因型。
我们发现，与 CC 基因型患者（0%）相比，T 等位基因携带者（37.2%）中 MA 的发生率显著更高，р < 0.0001。TT 基因型患者不仅更有可能出现伴随症状（仅在畏光方面存在显著差异），而且对偏头痛发作诱因更敏感。在 RP-VEP 测试结果中，我们观察到一种趋势，即与 CC 基因型患者相比，T 等位基因携带者的 N75/P100 振幅降低，并且正性习惯化指数更高。
因此，根据我们的数据，MTHFR 基因型与偏头痛的几个临床和电生理特征相关。
