月经周期中氧化应激的分析。
Analysis of oxidative stress during the menstrual cycle.
机构信息
Loyola University School of Medicine-Chicago, Chicago, USA.
出版信息
Reprod Biol Endocrinol. 2013 Aug 2;11:74. doi: 10.1186/1477-7827-11-74.
Abstract
BACKGROUND
Few data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.
METHODS
OS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.
RESULTS
From a base value (t1) of 284 +/- 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/- 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.
CONCLUSIONS
It may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.
摘要
背景
关于月经正常的女性在整个月经周期中血浆氧化应激（OS）的数据很少。
方法
通过测定血浆羟自由基水平（d-ROMs 试验），在 20 名健康志愿者的月经周期各阶段评估 OS。从第 1 天（t1）开始，每三天评估一次，直到月经周期结束（t27）。同时，在相同的时间间隔测定雌二醇（E2）和孕激素（P4）的水平。
结果
从基本值（t1）284±38.0 CARR.U.（基本上在正常范围内（<300 卡洛里单位或 CARR.U.）），OS 水平逐渐升高至 t15 的 378±115 CARR.U.，然后在随后的时间内略有下降，但平均水平仍高于 300 CARR.U.。E2 水平分析表明，最大的 OS 值出现在雌激素峰值附近，同时仍高于基础水平，然后在孕激素阶段下降，直到月经周期结束时恢复正常。
结论
健康女性可能有 2/3 的月经周期处于 OS 状态。
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