海洋蓝细菌采用的结构与功能的模块化策略：pitinoic 酸的表征与合成。
Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids.
机构信息
Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA.
出版信息
Org Lett. 2013 Aug 16;15(16):4050-3. doi: 10.1021/ol401396u. Epub 2013 Aug 5.
Abstract
Novel bioactive lipids were identified from a Guamanian cyanobacterium, the Pseudomonas aeruginosa quorum sensing inhibitor pitinoic acid A (1) and the anti-inflammatory pitinoic acids B (2) and C. The structure of 2 was confirmed by synthesis, which also allowed for biological evaluation. Since 2 is an ester of pitinoic acids A and C, it represents a prodrug strategy to liberate dual biological activity for the management of P. aeruginosa infections and their associated inflammation.
摘要
从关岛的一种蓝细菌中鉴定出新型生物活性脂质，绿脓杆菌群体感应抑制剂派啶酸 A（1）和具有抗炎活性的派啶酸 B（2）和 C。通过合成确定了 2 的结构，这也允许进行生物学评价。由于 2 是派啶酸 A 和 C 的酯，因此它代表了一种前药策略，可以释放双重生物学活性，用于治疗铜绿假单胞菌感染及其相关炎症。
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