Piccolo G, Franciotta D M, Camana C, Bergamaschi R, Banfi P, Sandrini G, Citterio A
Istituto Fondazione C. Mondino, Università di Pavia, Italy.
J Neurol. 1990 Jul;237(4):262-4. doi: 10.1007/BF00314631.
Sixteen cerebrospinal fluid (CSF) specimens serially obtained during long-term follow-up of two patients with Devic's neuromyelitis optica (DNO) were compared with 65 CSF samples from patients with multiple sclerosis (MS). By statistical analysis, the CSF profile in DNO was found to differ from that observed in MS, mainly showing pleocytosis, blood-brain barrier damage, and absence of persistent immunoglobulin G synthesis within the central nervous system. Oligoclonal bands, detected with isoelectric focusing, were present in CSF of 92% of the patients with MS, and in three CSF specimens from one patient with DNO during the first 6 months after disease onset. The bands disappeared in two subsequent samples. This finding has never been described in MS. One patient with DNO had an apparent chronic-relapsing course probably due to steroid dependence. The clinical and CSF features of our cases favour the nosographic independence of DNO and MS.
对两名视神经脊髓炎（DNO）患者长期随访期间连续采集的16份脑脊液（CSF）样本与65份多发性硬化症（MS）患者的脑脊液样本进行了比较。通过统计分析，发现DNO患者的脑脊液特征与MS患者不同，主要表现为细胞增多、血脑屏障损伤以及中枢神经系统内无持续性免疫球蛋白G合成。采用等电聚焦检测的寡克隆带在92%的MS患者脑脊液中存在，在一名DNO患者发病后的前6个月内，其3份脑脊液样本中也有寡克隆带。随后的两份样本中这些条带消失。这一发现从未在MS中被描述过。一名DNO患者有明显的慢性复发病程，可能是由于对类固醇依赖。我们病例的临床和脑脊液特征支持DNO和MS在疾病分类学上的独立性。
