视神经脊髓炎谱系疾病和多发性硬化中的寡克隆区带：多次脑脊液检查的差异
Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis: differences in repeated cerebrospinal fluid examinations.
作者信息
Bergamaschi R, Tonietti S, Franciotta D, Candeloro E, Tavazzi E, Piccolo G, Romani A, Cosi V
机构信息
Centre for Multiple Sclerosis, Neurological Institute IRCCS C. Mondino, University of Pavia, Pavia, Italy.
出版信息
Mult Scler. 2004 Feb;10(1):2-4. doi: 10.1191/1352458504ms988oa.
We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.
我们研究了视神经脊髓炎谱系疾病（Devic's neuromyelitis optica，NMO）和多发性硬化症（multiple sclerosis，MS）患者的多次脑脊液样本。两组中寡克隆带（oligoclonal bands，OBs）的变化趋势相反。在MS患者中，411例中有399例（97%）检测到OBs，且从未消失。在NMO患者中，11例中有3例（27%）检测到OBs，且总是消失。我们的研究结果支持了NMO和MS遵循不同发病机制途径的假说，这可能有助于NMO与MS的鉴别诊断。
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